Actions, Origins, Resistance

Author: Christopher Walsh

Publisher: Amer Society for Microbiology

ISBN: 9781555818937

Category: Medical

Page: 335

View: 3283

As antibiotics become deactivated through resistance and emerging bacterial diseases Christopher Walsh offers new insights into antibiotic modification and design. He shows how antibiotics work on targets and reviews recent strategies for finding innovative antibiotics to replace the last generation.

Ambulant erworbene Pneumonie

Author: Santiago Ewig

Publisher: Springer-Verlag

ISBN: 3662473127

Category: Medical

Page: 299

View: 2078

Dieses Buch bietet differenzierte Diagnostik und Therapie – was, wann, warum - zur sofortigen sicheren Anwendung. Entsprechend der neuesten Studien und Leitlinien aller wichtigen deutschen, europäischen und amerikanischen Fachgesellschaften. Es geht um eine der häufigsten akuten Erkrankungen in der Inneren Medizin in Deutschland mit erheblicher Hospital-Letalität von 4–10 % (höher als beim Myokardinfarkt). Oft wird die prognostische Bandbreite unterschätzt - auch Komplikationen und schwere Verläufe mit Multiorganversagen sind möglich. Grundlagen · Epidemiologie · Mikrobiologie und Immunologie (Differential-)Diagnostik, Prognose · Klinische Symptomatik und Untersuchungsbefunde · Radiologische Bildgebung · Labordiagnostik · Differentialdiagnostische Abgrenzung von Infektionen der unteren Atemwege (akute Bronchitis, akute Exazerbation der COPD) · Risikobeurteilung im Rahmen der Erstuntersuchung (Differential-)Therapie entsprechend Schweregrad Prävention, Nachsorge · Antimikrobiell · Adjunktiv · Bei Therapieversagen · Bei rezidivierender Pneumonie · Bei Aspirationspneumonie · In der Schwangerschaft · Als terminale Komplikation am Lebensende Strategie · Qualitätskontrolle der Behandlung · Arztbrief · Leitlinien Herausgeber Professor Dr. med. Santiago Ewig Chefarzt Thoraxzentrum Ruhrgebiet, Kliniken für Pneumologie und Infektiologie, EVK Herne und Augusta-Kranken-Anstalt Bochum.

Antibiotic Resistance

Implications for Global Health and Novel Intervention Strategies: Workshop Summary

Author: Institute of Medicine,Board on Global Health,Forum on Microbial Threats

Publisher: National Academies Press

ISBN: 0309156114

Category: Medical

Page: 496

View: 4142

Years of using, misusing, and overusing antibiotics and other antimicrobial drugs has led to the emergence of multidrug-resistant 'superbugs.' The IOM's Forum on Microbial Threats held a public workshop April 6-7 to discuss the nature and sources of drug-resistant pathogens, the implications for global health, and the strategies to lessen the current and future impact of these superbugs.

The Organic Chemistry of Drug Design and Drug Action

Author: Richard B. Silverman,Mark W. Holladay

Publisher: Academic Press

ISBN: 0123820316

Category: Medical

Page: 536

View: 8322

The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

Antimicrobial Drug Resistance

Mechanisms of Drug Resistance

Author: Douglas Mayers

Publisher: Springer Science & Business Media

ISBN: 9781597451802

Category: Medical

Page: 678

View: 2412

This ? rst edition of Antimicrobial Drug Resistance grew out of a desire by the editors and authors to have a comprehensive resource of information on antimicrobial drug resistance that encompassed the current information available for bacteria, fungi, protozoa and viruses. We believe that this information will be of value to clinicians, epidemiologists, microbiologists, virologists, parasitologists, public health authorities, medical students and fellows in training. We have endeavored to provide this information in a style which would be accessible to the broad community of persons who are concerned with the impact of drug resistance in our cl- ics and across the broader global communities. Antimicrobial Drug Resistance is divided into Volume 1 which has sections covering a general overview of drug resistance and mechanisms of drug resistance ? rst for classes of drugs and then by individual microbial agents including bacteria, fungi, protozoa and viruses. Volume 2 addresses clinical, epidemiologic and public health aspects of drug resistance along with an overview of the conduct and interpretation of speci? c drug resistance assays. Together, these two volumes offer a comprehensive source of information on drug resistance issues by the experts in each topic.

Molecular Techniques for the Study of Hospital Acquired Infection

Author: Steven L. Foley,Anne Y. Chen,Shabbir Simjee,Marcus J. Zervos

Publisher: John Wiley & Sons

ISBN: 9781118063835

Category: Medical

Page: 248

View: 8496

Providing a broad overview of the microbial pathogens associated with hospital-acquired human illness, Techniques for the Study of Hospital Acquired Infection examines the cost-effective use of laboratory techniques in nosocomial infectious disease epidemiology and control. This concise guide addresses the cost benefits of combining modern molecular techniques with the traditional activities of infection control departments. The book is useful as a guide to hospital infection control programs as well as a text for medical practitioners, grad/medical students, researcher scientists, population biologists, molecular biologists, and microbiologists.

Antibiotic and Chemotherapy E-Book

Author: Roger G. Finch,David Greenwood,Richard J. Whitley,S. Ragnar Norrby

Publisher: Elsevier Health Sciences

ISBN: 0702047651

Category: Medical

Page: 916

View: 8757

Well-respected and widely regarded as the most comprehensive text in the field, Antibiotic and Chemotherapy, 9th Edition by Drs. Finch, Greenwood, Whitley, and Norrby, provides globally relevant coverage of all types of antimicrobial agents used in human medicine, including all antiviral, antiprotozoan and anthelminthic agents. Comprehensively updated to include new FDA and EMEA regulations, this edition keeps you current with brand-new information about antiretroviral agents and HIV, superficial and mucocutaneous myscoses and systemic infections, management of the immunocompromised patient, treatment of antimicrobial resistance, plus coverage of new anti-sepsis agents and host/microbe modulators. Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Offer the best possible care and information to your patients about the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Stay current with 21 new chapters including the latest information on superficial and mucocutaneous mycoses, systemic infections, anti-retroviral agents, and HIV. Get fresh perspectives and insights thanks to 21 newly-authored and extensively re-written chapters. Easily access information thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Apply the latest treatments for anti-microbial organisms such as MRSA, and multi-drug resistant forms of TB, malaria and gonorrhea. Keep up on the latest FDA and EMEA regulations.

ASM News

Author: N.A

Publisher: N.A


Category: Microbiology

Page: N.A

View: 1216

Magill's Medical Guide

Author: Anne Ed Chang,Laurence M. Katz, M.D.

Publisher: Salem Pr Inc

ISBN: 9781587651595

Category: Medical

Page: 2938

View: 1881

Magill's Medical Guide provides readers with the most authoritative yet accessible reference source in its field. The Guide bridges the gap between professional medical encyclopedias and dictionaries and popular self-help guides.

Magill's Medical Guide: Down syndrome-Laser use in surgery

Author: Anne Chang

Publisher: N.A

ISBN: 9781587651618

Category: Medical

Page: 2938

View: 6457

Thrombolytic therapy & TPA, Thrombosis & thrombus, Thumb sucking, Thyroid disorders, Thyroid gland, Thyroidectomy, Tics, Toilet training, Tonsillectomy & adenoid removal, Tonsillitis, Tooth extraction, Toothache, Torticollis, Touch, Touretteʼs syndrome, Toxemia, Toxic shock syndrome, Toxicology, Toxoplasmosis, Tracheostomy, Trachoma, Transfusion, Transient ischemic attacks (TIAs), Transplantation, Tremors, Trichinosis, Trichomoniasis, Tropical medicine, Tubal ligation, Tuberculosis, Tumor removal, Tumors, Turner syndrome, Typhoid fever & typhus, Ulcer surgery, Ulcers, Ultrasonography, Umbilical cord, Unconsciousness, Upper extremities, Urethritis, Urinalysis, Urinary disorders, Urinary system, Urology, Urology, pediatric, Vagotomy, Varicose vein removal, Varicose veins, Vascular medicine, Vascular system, Vasectomy, Venous insufficiency, Veterinary medicine, Viral infections, Visual disorders, Vitamins & minerals, Voice & vocal cord disorders, Von Willebrandʼs disease, Warts, Weaning, Weight loss & gain, Weight loss medications, Well baby examinations, West Nile virus, Whiplash, Whooping cough, Wilsonʼs disease, Wisdom teeth, Wiskott Aldrich syndrome, World Health Organization, Worms, Wounds, Wrinkles, Xenotransplantation, Yellow fever, Yoga, Zoonoses, Glossary, Diseases & Other Medical Conditions, Types of Health Care Providers, Medical Journals, Web Site Directory, Entries by Anatomy or System Affected, Entries by Specialties & Related Fields.

Magill's Medical Guide: Corticosteroids - Heel spur removal

Author: Anne Chang

Publisher: Salem PressInc

ISBN: 9781587653865

Category: Medical

Page: 3104

View: 6937

Covers diseases, disorders, treatments, procedures, specialties, anatomy, biology, and issues in an A-Z format, with sidebars addressing recent developments in medicine and concise information boxes for all diseases and disorders.

Medicine, Health, and Bioethics

Essential Primary Sources

Author: K. Lee Lerner,Brenda Wilmoth Lerner

Publisher: Gale / Cengage Learning


Category: Medical

Page: 513

View: 5977

A focus on leading social issues of the 19th, 20th, and 21st centuries. Each title contains approximately 175 full or excerpted documents--speeches, legislation, magazine and newspaper articles, essays, memoirs, letters, interviews, novels, songs, and works of art--as well as overview information that places each document in context.


Challenges, Mechanisms, Opportunities

Author: Christopher Walsh,Timothy Wencewicz

Publisher: N.A

ISBN: 9781555819309

Category: Medical

Page: 477

View: 9085

Antibiotics: Challenges, Mechanisms, Opportunitiesdetails the contemporary challenges for discovery, optimization, and advancement of new antibiotics. It focuses on discovery not preclinical or clinical development. Given that the few classes of clinically significant antibiotics are all small molecules, this book focuses on the molecular structures and characteristics of both natural and synthetic antibacterial agents. Antibioticsis a valuable reference for microbiologists, bacterial physiologists, geneticists, pharmacologists, and drug developers.

Microbial Biofilms

Author: Mahmoud Afif Ghannoum,George A. O'Toole

Publisher: Amer Society for Microbiology

ISBN: 9781555812942

Category: Medical

Page: 426

View: 8398

first introductory volume detailing this new and important field of microbial research; covers broad topics in biofilm biology including development, antibiotic resistance, architecture, and role of these communities in disease; combines cutting edge research with historical perspective of the field.

Resistant Infections

Author: Debra A. Miller

Publisher: Greenhaven


Category: Juvenile Nonfiction

Page: 200

View: 798

Essays discuss the seriousness, causes, and possible solutions for drug-resistant infections.

The small molecule microarray synthesis platform

development and applications in chemical biology

Author: Matthew D. Bowman,The University of Wisconsin - Madison

Publisher: ProQuest



Page: 308

View: 7772

We have synthesized a robust cellulose-based support platform that is stable to a broad range of organic reaction conditions. To probe the reaction scope of our cellulose support system, we first synthesized chalcone macroarrays. The chalcones were transformed easily into a range of different heterocycles, allowing us to prepare macroarrays of pyrimidines, cyanopyridines, triarylpyridines, and deazalumazines in high purity.

Biologie der Antibiotica

Author: H. Zähner

Publisher: Springer-Verlag

ISBN: 3642949282

Category: Medical

Page: 114

View: 2798