Chemical Projects Scale Up

How to go from Laboratory to Commercial

Author: Joe M. Bonem

Publisher: Elsevier

ISBN: 0128137282

Category: Technology & Engineering

Page: 232

View: 6597

Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Concepts of Chemical Engineering 4 Chemists

Author: Stefaan J. R. Simons,Royal Society of Chemistry (Great Britain)

Publisher: Royal Society of Chemistry

ISBN: 0854049517

Category: Science

Page: 350

View: 1185

Based on the popular course of the same title, Concepts of Chemical Engineering 4 Chemists outlines the basic aspects of chemical engineering for chemistry professionals. It clarifies the terminology used and explains the systems methodology approach to process design and operation for chemists with limited chemical engineering knowledge. The book provides practical insights into all areas of chemical engineering, including such aspects as pump design and the measurement of key process variables. The calculation of design parameters, such as heat and mass transfer coefficients, and reaction scale-up are also discussed, as well as hazard analysis, project economics and process control. Designed as a reference guide, it is fully illustrated and includes worked examples as well as extensive reference and bibliography sections. Concepts of Chemical Engineering 4 Chemists is ideal for those who either work alongside chemical engineers or who are embarking on chemical engineering-type projects.

Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier

ISBN: 0444627391

Category: Technology & Engineering

Page: 112

View: 4524

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527607765

Category: Science

Page: 296

View: 6519

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Pilot Plants and Scale-up of Chemical Processes II

Author: William Hoyle

Publisher: N.A

ISBN: 9780854047192

Category: Science

Page: 120

View: 9389

How do you translate bench chemistry into 10 -100 litre pilot plant scale? Drawing on the wealth of experience of its expert contributors, Pilot Plants and Scale-up of Chemical Processes II provides an insight into how methods, procedures and techniques can be optimised. Up-to-date and highly focused, this book addresses topics including the choice of phase-transfer catalyst, safe scale-up of both Grignard and organolithium reactions, and on-line techniques for examining crystallisation. Newly established collaborative industry/academia projects are discussed, along with other procedures that have a practical application in industry. As a source of innovative techniques and best current practice, this book is a must for process development and pilot plant chemists as well as chemical engineers.

Scaleup of chemical processes

conversion from laboratory scale tests to successful commercial size design

Author: Attilio Bisio,Robert L. Kabel

Publisher: Wiley-Interscience

ISBN: N.A

Category: Technology & Engineering

Page: 699

View: 9573

Mixing in Continuous Flow Systems E. B. Nanman and B. A. Buffham This groundbreaking introductory study lets engineers and research scientists design and analyze complex flow and reaction systems, even with limited data. Specifically dealing with mixing effects important to the design of chemical reactors, it uses systems models typical of any large chemical plant or oil refinery to examine temporal mixing, or the mixing among particles or any conserved entities that have remained in the system for different lengths of time. In addition, it views mixing from a spatial perspective, treating it as a process that brings system components into closer physical proximity. Plus it reports the first steps toward unification of the temporal and spatial viewpoints of mixing. 1983 (0 471-86191-X) 271 pp. Structural Analysis and Design of Process Equipment Maan H. Jawad and James R. Farr Here is the most practical, up-to-date source available for information on the analysis and design of process equipment. It provides practicing engineers with clear guidance to the latest ASME Boiler and Vessel Code and offers advanced engineering students a concise introduction to the basic equations and rules used in the design of process vessels and components. Topics covered include a general introduction to the tools of the trade.an outline of the basic theory of plates and shells.a detailed analysis and design of components, defining procedures for designing vessel supports and illustrating the evaluation of stress due to wind and earthquake loads.and the design and analysis of specialized equipment, including tubesheet design in heat transfer equipment. 1984 (0 471-09207-X) 704 pp. Gas Treating with Chemical Solvents G. Astarita, D. W. Savage, and A. Bisio This rigorous blend of theory and practice provides a rational analysis of gas treating processes in which liquids are used to absorb acid gases from gaseous streams. It emphasizes those aspects unique to the use of chemically reactive solvents--liquids containing components that react chemically with the acid gases after they dissolve in the liquid phase And it also treats those aspects common to purely physical acid gas absorption processes. An ideal text for graduate students with a working knowledge of physical chemistry, classical gas absorption and mass transfer processes, it constitutes an exhaustive treatment of four important areas: industrial gas treating, theory, applications, and industrial problems. 1983 (0 471-05768-1) 493 pp.

An Applied Guide to Process and Plant Design

Author: Sean Moran

Publisher: Butterworth-Heinemann

ISBN: 0128003820

Category: Technology & Engineering

Page: 390

View: 9728

An Applied Guide to Process and Plant Design is a guide to process plant design for both students and professional engineers. The book covers plant layout and the use of spreadsheet programmes and key drawings produced by professional engineers as aids to design; subjects which are usually learned on the job rather than in education. You will learn how to produce smarter plant design through the use of computer tools, including Excel and AutoCAD, "What If Analysis", statistical tools, and Visual Basic for more complex problems. The book also includes a wealth of selection tables, covering the key aspects of professional plant design which engineering students and early-career engineers tend to find most challenging. Professor Moran draws on over 20 years' experience in process design to create an essential foundational book ideal for those who are new to process design, compliant with both professional practice and the IChemE degree accreditation guidelines. Explains how to deliver a process design that meets both business and safety criteria Covers plant layout and the use of spreadsheet programmes and key drawings as aids to design Includes a comprehensive set of selection tables, covering those aspects of professional plant design which early-career designers find most challenging

Dimensional Analysis and Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: Springer Science & Business Media

ISBN: 3642766730

Category: Science

Page: 178

View: 9457

Contemporary Chemical Process Engineers face complex design and research problems. Temperature-dependent physical properties and non-Newtonian flow behavior of substances in a process cannot be predicted by numerical mathematics. Scaling-up equipment for processing can often only be done with partial similarity methods. Standard textbooks often neglect topics like dimensional analysis, theory of similarity and scale-up. This book fills this gap! It is aimed both at university students and the process engineer. It presents dimensional analysis very comprehensively with illustrative examples of mechanical, thermal and chemical processes.

Food Processing Operations and Scale-up

Author: Kenneth J. Valentas,J. Peter Clark,Leon Levin

Publisher: CRC Press

ISBN: 9780824782795

Category: Technology & Engineering

Page: 408

View: 2958

Intended for students and practitioners who have a basic education in chemical engineering or food science. Contains basic information in each area and describes some of the fundamental ideas of processing development and design. Examines the food industry structure, how it works, consumer products,

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Elsevier

ISBN: 0080514480

Category: Science

Page: 354

View: 3580

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

Chemical engineering design

principles, practice and economics of plant and process design

Author: Gavin P. Towler,R. K. Sinnott

Publisher: Butterworth-Heinemann

ISBN: N.A

Category: Technology & Engineering

Page: 1245

View: 9882

"Bottom line: For a holistic view of chemical engineering design, this book provides as much, if not more, than any other book available on the topic." --Extract from Chemical Engineering Resources review. Chemical Engineering Design is one of the best-known and widely adopted texts available for students of chemical engineering. It deals with the application of chemical engineering principles to the design of chemical processes and equipment. Revised throughout, this US edition has been specifically developed for the US market. It covers the latest aspects of process design, operations, safety, loss prevention and equipment selection, among others. Comprehensive in coverage, exhaustive in detail, it is supported by extensive problems and a separate solutions manual for adopting tutors and lecturers. In addition, the book is widely used by professions as a day-to-day reference.

Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 352763715X

Category: Science

Page: 370

View: 7355

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

How to Scale-Up a Wet Granulation End Point Scientifically

Author: Michael Levin

Publisher: Academic Press

ISBN: 0128035609

Category: Medical

Page: 88

View: 2806

How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point. Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process. Thoroughly referenced and based on the latest research and literature Part of the Expertise in Pharmaceutical Process Technology Series edited by internationally respected expert, Michael Levin Illustrates the most common problems related to scale-up of a wet granulation end point and provides valuable insights on how to solve these problems in a practical way

Advanced Data Analysis and Modelling in Chemical Engineering

Author: Denis Constales,Gregory S. Yablonsky,Dagmar R. D'hooge,Joris W. Thybaut,Guy B. Marin

Publisher: Elsevier

ISBN: 0444594841

Category: Technology & Engineering

Page: 414

View: 1385

Advanced Data Analysis and Modeling in Chemical Engineering provides the mathematical foundations of different areas of chemical engineering and describes typical applications. The book presents the key areas of chemical engineering, their mathematical foundations, and corresponding modeling techniques. Modern industrial production is based on solid scientific methods, many of which are part of chemical engineering. To produce new substances or materials, engineers must devise special reactors and procedures, while also observing stringent safety requirements and striving to optimize the efficiency jointly in economic and ecological terms. In chemical engineering, mathematical methods are considered to be driving forces of many innovations in material design and process development. Presents the main mathematical problems and models of chemical engineering and provides the reader with contemporary methods and tools to solve them Summarizes in a clear and straightforward way, the contemporary trends in the interaction between mathematics and chemical engineering vital to chemical engineers in their daily work Includes classical analytical methods, computational methods, and methods of symbolic computation Covers the latest cutting edge computational methods, like symbolic computational methods

Process Chemistry in the Pharmaceutical Industry

Author: Kumar Gadamasetti

Publisher: CRC Press

ISBN: 9780824719814

Category: Medical

Page: 500

View: 5121

Providing guidance for chemists and other scientists entering pharmaceutical discovery and development, this up-to-the-minute reference presents contributions from an international group of nearly 50 renowned researchers—offering a solid grounding in synthetic and physical organic chemistry, and clarifying the roles of various specialties in the development of new drugs. Featuring over 1000 references, tables, and illustrations, Process Chemistry in the Pharmaceutical Industry is sure to find its way to the bookshelves of organic, physical, analytical, process, and medicinal chemists and biochemists; pharmacists; and upper-level undergraduate and graduate students in these disciplines.

Groundwater Arsenic Remediation

Treatment Technology and Scale UP

Author: Parimal Pal

Publisher: Butterworth-Heinemann

ISBN: 012801377X

Category: Technology & Engineering

Page: 326

View: 5661

Arsenic abatement from groundwater in locations with a central water distribution system is relatively simple. The real challenge is selecting the most effective and affordable treatment and scale up option for locations which lack the appropriate infrastructure. Groundwater Arsenic Remediation: Treatment Technology and Scale UP provides the latest breakthrough groundwater treatment technologies and modeling and simulation methods for project scale up and eventually field deployment in locations which lack the proper central water distribution system to ensure arsenic free groundwater. Covers the different removal methods, such as chemical, adsorption, separation by membranes, and membrane distillation Includes the state-of-the-art modeling & simulation methods for optimization and field deployment Provides economic and comparative analysis of each arsenic treatment technology

Scaling Up Excellence

Getting to More Without Settling for Less

Author: Robert I. Sutton,Huggy Rao

Publisher: Crown Business

ISBN: 0385347030

Category: Business & Economics

Page: 368

View: 9047

Wall Street Journal Bestseller "The pick of 2014's management books." –Andrew Hill, Financial Times "One of the top business books of the year." –Harvey Schacter, The Globe and Mail Bestselling author, Robert Sutton and Stanford colleague, Huggy Rao tackle a challenge that determines every organization’s success: how to scale up farther, faster, and more effectively as an organization grows. Sutton and Rao have devoted much of the last decade to uncovering what it takes to build and uncover pockets of exemplary performance, to help spread them, and to keep recharging organizations with ever better work practices. Drawing on inside accounts and case studies and academic research from a wealth of industries-- including start-ups, pharmaceuticals, airlines, retail, financial services, high-tech, education, non-profits, government, and healthcare-- Sutton and Rao identify the key scaling challenges that confront every organization. They tackle the difficult trade-offs that organizations must make between whether to encourage individualized approaches tailored to local needs or to replicate the same practices and customs as an organization or program expands. They reveal how the best leaders and teams develop, spread, and instill the right mindsets in their people-- rather than ruining or watering down the very things that have fueled successful growth in the past. They unpack the principles that help to cascade excellence throughout an organization, as well as show how to eliminate destructive beliefs and behaviors that will hold them back. Scaling Up Excellence is the first major business book devoted to this universal and vexing challenge and it is destined to become the standard bearer in the field.

Adsorption, Ion Exchange and Catalysis

Design of Operations and Environmental Applications

Author: Stavros G. Poulopoulos,Vassilis J. Inglezakis

Publisher: Elsevier

ISBN: 9780080463667

Category: Technology & Engineering

Page: 614

View: 9185

Adsorption, Ion Exchange and Catalysis is essentially a mixture of environmental science and chemical reactor engineering. More specifically, three important heterogeneous processes, namely, adsorption, ion exchange and catalysis, are analysed, from fundamental kinetics to reactor design with emphasis on their environmental applications. In Chapter 1, the subject of air and water pollution is dealt with. Data about pollutants and emission sources are given and the treatment methods are shortly presented. In Chapter 2, the very basics and historical development of adsorption, ion exchange and catalysis are presented as well as their environmental applications. Chapter 3 is devoted to heterogeneous processes and reactor analysis. All types of reactors are described in depth and reactor modelling, hydraulics and mass/heat transfer phenomena are examined for each type of reactor. Chapters 4 and 5 are dedicated to adsorption & ion exchange and catalysis, respectively. The basic principles are presented including kinetics, equilibrium, mass/heat transfer phenomena as well as the analytical solutions of the reactor models presented in Chapter 3. In the sixth chapter, the subject of scale up is approached. The two Annexes at the end of the book contain physical properties of substances of environmental interest as well as unit conversion tables. Finally, nearly all the examples contained are based on real experimental data found in literature with environmental interest. Most of the examples consider all aspects of operation design – kinetics, hydraulics and mass transfer. * Provides basic knowledge of major environmental problems and connects them to chemical engineering

Silent Spring

Author: Rachel Carson

Publisher: Houghton Mifflin Harcourt

ISBN: 9780618249060

Category: Nature

Page: 378

View: 1987

Discusses the reckless annihilation of fish and birds by the use of pesticides and warns of the possible genetic effects on humans.

Novel Catalytic and Separation Processes Based on Ionic Liquids

Author: Dickson Ozokwelu,Suojiang Zhang,Obiefuna Okafor,Weiguo Cheng,Nicholas Litombe

Publisher: Elsevier

ISBN: 0128020555

Category: Technology & Engineering

Page: 280

View: 9655

Novel Catalytic and Separation Process Based on Ionic Liquids presents the latest progress on the use of ionic liquids (ILs) in catalytic and separation processes. The book discusses the preparation of ILs, the characterization of IL catalysts by spectroscopic techniques, catalytic reactions over IL catalysts, separation science and technology of ILs, applications in biomass utilization, and synthesis of fine chemicals. Scientists, engineers, graduate students, managers, decision-makers, and others interested in ionic liquids will find this information very useful. The book can be used as a springboard for more advanced work in this area as it contains both theory and recent applications, research conducted, and developments in separation techniques and catalysis using ionic liquids. Presents new preparation and advanced characterization of ionic liquids catalysts Outlines catalytic reactions using ionic liquid, thus showing higher yields and selectivity Presents novel separation science and technology based on ionic liquids and non-thermal processes