Author: Julie Fisher,John Arnold
Publisher: Garland Science
Instant Notes in Chemistry for Biologists is a concise book for undergraduates who have a limited background in chemistry. This book covers the main concepts in chemistry, provides simple explanations of chemical terminology, and illustrates underlying principles and phenomena in the life sciences with clear biological examples. Building on the success of the first edition, the second edition has been fully revised and updated and comprises new sections on water as a biological solvent, inorganic molecules and biological macromolecules.
Author: David Reed
Publisher: Pearson Higher Ed
Chemistry for Biologists provides a focused yet chemically and mathematically rigorous introduction to those key aspects of chemistry that form the basis of biological processes. Written in a straightforward, accessible style, the book begins with an overview of basic chemical concepts. Building on these core principles, the reader is guided through subjects such as the structure and properties of organic molecules, equilibria, energetics, kinetics, biomolecules, reaction mechanisms, metabolism and structural methods. The relevance of each chemical concept to the study of biology is clearly explained at every stage, enabling students to develop a deep appreciation of the chemistry that underpins their chosen subject, and become confident in applying this knowledge to their own studies.
Author: Julie Fisher,John Arnold
Publisher: Taylor & Francis
"Knowledge you need in an instant! BIOS Instant Notes in Chemistry for Biologists, Third Edition, is the perfect text for undergraduates looking for a concise introduction to the subject, or a study guide to use before examinations. Each topic begins with a summary of essential facts-an ideal revision checklist-followed by a description of the subject that focuses on core information, with clear, simple diagrams that are easy for students to understand and recall in essays and exams. BIOS Instant Notes in Chemistry for Biologists, Third Edition, is fully up-to-date and covers: The elements -- Chemical bonds and molecular shape -- Water- the biological solvent -- Carbon, the basis for life on Earth -- 3D-molecular structure of organic compounds -- Small inorganic molecules of biological importance -- Some metals in biology -- Molecular interactions -- Common reaction types of carbon based compounds -- Organic compounds by chemical class -- Aromatic compounds -- Chemical synthesis of biological molecules -- Important biological macromolecules by class -- Aqueous behaviour -- Elementary thermodynamics -- Kinetics -- Spectroscopy -- Appendix "--
Author: Bernard Rockett,Raul Sutton
This is a self-study guide covering the main chemical concepts needed for Advanced level biology and life science courses. It is intended for students of A and AS level biology and human biology, HND life sciences and environmental science and equivalent courses.
The Essential Concepts
Author: Jonathan Crowe,Tony Bradshaw
Publisher: Oxford University Press
Chemistry pervades our life. It moulds our climate, fuels our transport, gives food its taste and smell. Most of all, chemistry powers life itself. Chemistry for the Biosciences leads students through the essential concepts of chemistry that are central to understanding biological systems, using everyday examples and analogies to help them get to grips with the subject. With an emphasis on clear, straightforward explanations, it features biological examples throughout to illustrate just how integral chemistry is to the biosciences. With topics drawn from organic, physical and inorganic chemistry, students will encounter a broad range of essential concepts to master. Chemistry for the Biosciences includes many learning features - both in print and online - to help students grasp these concepts as quickly and thoroughly as possible. From the self-check questions throughout each chapter to help consolidate learning, to the Chemical Toolkits and Maths Tools that help students explore terminology, methods, and numerical skills that may be unfamiliar, the book is written to be a true course companion for students on biological and biomedical science degrees - one that will help them not only remember the essentials, but really understand them, setting students up for success in their later studies.
Author: Dr. Catherine Louis,Catherine Louis,Olivier Pluchery
Publisher: World Scientific
In 2006, "Or-Nano," a French scientific network on gold nanoparticles was created in France. The research group saw the need for a gathering of specialists on gold nanoparticles to facilitate deeper scientific exchange between the different scientific communities. The result is this book which provides a broad introduction to the fascinating and beautiful world of gold nanoparticles. This volume traces the fascinating history of gold nanoparticles which began in ancient times with red ruby glass, and reached its zenith at the end of the 17th century. It also provides an in-depth investigation into the use of gold nanoparticles over the ages an important aspect that is almost never treated in scientific books. Each chapter provides a lucid overview of the different aspects of gold nanoparticles including synthesis, optical and thermal properties, interaction with surfaces, catalysis, reactivity, biosensors, and nanomedicine. There is an ample focus on promising fields where gold nanoparticles are already creating breakthroughs such as in catalysis, cancer therapy and plasmonics. The issue of toxicity is also discussed comprehensively. The work may be used as an advanced textbook by graduate students and young scientists who need an introduction to gold nanoparticles. It will also be suitable for experts in the related areas of chemistry, biology, material science, and physics, who are interested to broaden their knowledge and provide an overview of the subject. The explanations in the book are detailed enough to capture the interest of the reader, and complete enough to provide the necessary background material needed to delve further into the subject and explore the literature.
Author: Pier Luigi Luisi,Cristiano Chiarabelli
Publisher: John Wiley & Sons
Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.
Author: Erich Kombrink,Markus Kaiser
Publisher: Frontiers Media SA
Biologically active small molecules have increasingly been applied in plant biology to dissect and understand biological systems. This is evident from the frequent use of potent and selective inhibitors of enzymes or other biological processes such as transcription, translation, or protein degradation. In contrast to animal systems, which are nurtured from drug research, the systematic development of novel bioactive small molecules as research tools for plant systems is a largely underexplored research area. This is surprising since bioactive small molecules bear great potential for generating new, powerful tools for dissecting diverse biological processes. In particular, when small molecules are integrated into genetic strategies (thereby defining “chemical genetics”), they may help to circumvent inherent problems of classical (forward) genetics. There are now clear examples of important, fundamental discoveries originating from plant chemical genetics that demonstrate the power, but not yet fully exploited potential, of this experimental approach. These include the unraveling of molecular mechanisms and critical steps in hormone signaling, activation of defense reactions and dynamic intracellular processes. The intention of this Research Topic of Frontiers in Plant Physiology is to summarize the current status of research at the interface between chemistry and biology and to identify future research challenges. The research topic covers diverse aspects of plant chemical biology, including the identification of bioactive small molecules through screening processes from chemical libraries and natural sources, which rely on robust and quantitative high-throughput bioassays, the critical evaluation and characterization of the compound’s activity (selectivity) and, ultimately, the identification of its protein target(s) and mode-of-action, which is yet the biggest challenge of all. Such well-characterized, selective chemicals are attractive tools for basic research, allowing the functional dissection of plant signaling processes, or for applied purposes, if designed for protection of crop plants from disease. New methods and data mining tools for assessing the bioactivity profile of compounds, exploring the chemical space for structure–function relationships, and comprehensive chemical fingerprinting (metabolomics) are also important strategies in plant chemical biology. In addition, there is a continuing need for diverse target-specific bioprobes that help profiling enzymatic activities or selectively label protein complexes or cellular compartments. To achieve these goals and to add suitable probes and methods to the experimental toolbox, plant biologists need to closely cooperate with synthetic chemists. The development of such tailored chemicals that beyond application in basic research can modify traits of crop plants or target specific classes of weeds or pests by collaboration of applied and academic research groups may provide a bright future for plant chemical biology. The current Research Topic covers the breadth of the field by presenting original research articles, methods papers, reviews, perspectives and opinions.
A New Introduction to Molecular Structure and Function
Author: Robert R. Crichton
Biological Inorganic Chemistry: A New Introduction to Molecular Structure and Function, Second Edition, provides a comprehensive discussion of the biochemical aspects of metals in living systems. Beginning with an overview of metals and selected nonmetals in biology, the book then discusses the following concepts: basic coordination chemistry for biologists; structural and molecular biology for chemists; biological ligands for metal ions; intermediary metabolism and bioenergetics; and methods to study metals in biological systems. The book also covers metal assimilation pathways; transport, storage, and homeostasis of metal ions; sodium and potassium channels and pumps; magnesium phosphate metabolism and photoreceptors; calcium and cellular signaling; the catalytic role of several classes of mononuclear zinc enzymes; the biological chemistry of iron; and copper chemistry and biochemistry. In addition, the book discusses nickel and cobalt enzymes; manganese chemistry and biochemistry; molybdenum, tungsten, vanadium, and chromium; non-metals in biology; biomineralization; metals in the brain; metals and neurodegeneration; metals in medicine and metals as drugs; and metals in the environment. Winner of a 2013 Textbook Excellence Awards (Texty) from the Text and Academic Authors Association Readable style, complemented by anecdotes and footnotes Enables the reader to more readily grasp the biological and clinical relevance of the subject Color illustrations enable easy visualization of molecular mechanisms
Author: Stephen Collier Wallwork
Category: Chemistry, Pharmaceutical
Author: David Van Vranken,Gregory A. Weiss
Publisher: Garland Science
Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.
Author: Gordon G. Hammes
Publisher: John Wiley & Sons
Gain a practical, working knowledge of the physical chemistry essential for the biological sciences Physical Chemistry for the Biological Sciences is an excellent resource for biochemistry and biology/health science professionals and students who need a basic understanding of thermodynamics, kinetics, hydrodynamics of macromolecules, and spectroscopy in order to explore molecular structure and chemical reactions. Approachable, yet thorough, the book presents physical chemistry in conceptual terms with a minimum of mathematics. Providing the basic knowledge and tools that every biologist should have to understand the quantitative interpretation of biological phenomena, it covers: Fundamentals of thermodynamics and chemical kinetics Fundamentals of spectroscopy and structure determination Ligand binding to macromolecules, hydrodynamics, and mass spectrometry All techniques and concepts are clearly illustrated with relevant applications and examples from the biological sciences. Problems at the end of each chapter reinforce the principles. This is a succinct reference for practitioners, including bioorganic chemists, medicinal chemists, biochemists, pharmaceutical chemists, biologists, and professionals in fields such as pharmaceuticals, agriculture, and biotechnology. It's also an excellent textbook for graduate and upper-level undergraduate students in biochemistry, biology, and related fields.
Author: Antony D. Buss,Mark S. Butler,Royal Society of Chemistry (Great Britain)
Publisher: Royal Society of Chemistry
This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.
A User's Introduction for Biologists, Chemists and Informaticians
Author: ERIC MARECHAL,Sylvaine Roy,Laurence Lafanechère
Publisher: Springer Science & Business Media
Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline. This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.
In Vitro Techniques
Author: John J. Correia,H. William Detrich, III
Publisher: Academic Press
Driven in part by the development of genomics, proteomics, and bioinformatics as new disciplines, there has been a tremendous resurgence of interest in physical methods to investigate macromolecular structure and function in the context of living cells. This volume in Methods in Cell Biology is devoted to biophysical techniques in vitro and their applications to cellular biology. Biophysical Tools for Biologists covers methods-oriented chapters on fundamental as well as cutting-edge techniques in molecular and cellular biophysics. This book is directed toward the broad audience of cell biologists, biophysicists, pharmacologists, and molecular biologists who employ classical and modern biophysical technologies or wish to expand their expertise to include such approaches. It will also interest the biomedical and biotechnology communities for biophysical characterization of drug formulations prior to FDA approval. Describes techniques in the context of important biological problems Delineates critical steps and potential pitfalls for each method Includes full-color plates to illustrate techniques
Author: Gerry P. Quinn,Michael J. Keough
Publisher: Cambridge University Press
Regression, analysis of variance, correlation, graphical.
Publisher: Academic Press
Alkaloids are a major group of natural products derived from a variety of organisms, which are widely used as medicinal and biological agents. This Series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, this Series, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. Over the years, this Series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile. Indispensable reference work written by leading experts in the field Provides up-to-date, timely reviews on compounds and classes of great interest Covers synthesis, biosynthesis, biology, as well as isolation and structure elucidation An essential research tool for anyone working with alkaloids from a chemical or biological perspective
Author: Annette Beck-Sickinger,Peter Weber
Publisher: John Wiley & Sons
Combinatorial chemistry has taken the pharmaceutical industry bystorm over the past ten to fifteen years. There has been a massiveinvestment in automation by pharmaceutical companies and a demandfor graduates/PhDs with experience and knowledge of combinatorialchemistry. These days the academic education of chemists andbiologists is gradually converging, so those entering thepharmaceutical industry need to be not only chemistry graduates butalso biologists applying their biological knowledge to chemistry. Many chemists, however, still require experience in biologicalmethods and similarly biologists have not yet realized the power ofchemical methods. This book will therefore help ease the transitionfrom biology into chemistry and vice versa, for those working inthe combinatorial chemistry field. Because combinatorial chemistryevolved from the requirements of the biology field, the authorshave written this book with both biologists and chemists inmind. Combinatorial chemistry is a new and highly influential area ofmodern synthetic chemistry based on efficient, parallel synthesisof molecules, as opposed to the use of several synthetic steps, toproduce many sets of compounds for biological evaluation. Thetechniques used in this area are key to the discovery of new drugcompounds in the pharmaceutical and agrochemical industries.Combinatorial Methods in Chemistry and Biology describes theorigins, basics and techniques used both in combinatorial chemistryand molecular biology. Key features: First book to cover combinatorial methods in both chemistry andbiology - ideal for those with either a chemical or biologicalbackground. Introductory text - ideal for newcomers to the field. Covers a wide swathe of techniques and topics - providingbeginners with a complete overview of the field. Contains chapters on supporting material and linkers, twoimportant areas in the field. Up-to-date and topical. This volume will be of key interest to technicians/scientistsworking in the pharmaceutical industry with backgrounds in eitherbiology or chemistry. It will also be invaluable to students -postgraduates studying chemistry and molecular biology or thosechemistry/molecular biology undergraduates at universities wherecombinatorial chemistry is taught as a module.