Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier

ISBN: 0444627391

Category: Technology & Engineering

Page: 112

View: 1794

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Scale-up Methodology for Chemical Processes

Author: Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier

Publisher: Editions TECHNIP

ISBN: 9782710806462

Category: Technology & Engineering

Page: 240

View: 2256

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Pharmaceutical Process Scale-Up

Author: Michael Levin

Publisher: CRC Press

ISBN: 082474196X

Category: Medical

Page: 584

View: 8486

Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling, granulation and drying, fluid bed applications, compaction and tableting, and film coating and regulatory requirements for scale-up and postapproval changes. Drawing on the experience of twenty contributing researchers, the book employs dimensional analysis as a unified scientific approach to quantify similar processes on different scales.

Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 352763715X

Category: Science

Page: 370

View: 9237

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Pharmaceutical Process Scale-Up, Third Edition

Author: Michael Levin

Publisher: CRC Press

ISBN: 9781616310011

Category: Medical

Page: 530

View: 3199

The third edition of Pharmaceutical Process Scale-Up deals with the theory and practice of scale-up in the pharmaceutical industry. This thoroughly revised edition reflects the rapid changes in the field and includes: New material on tableting scale-up and compaction. Regulatory appendices that cover FDA and EU Guidelines. New chapters on risk evaluation and validation as related to scale-up. Practical advice on scale-up solutions from world renowned experts in the field. Pharmaceutical Process Scale-Up, Third Edition will provide an excellent insight in to the practical aspects of the process scale-up and will be an invaluable source of information on batch enlargement techniques for formulators, process engineers, validation specialists and quality assurance personnel, as well as production managers. It will also provide interesting reading material for anyone involved in Process Analytical Technology (PAT), technology transfer and product globalization.

Scaleup and Design of Industrial Mixing Processes

Author: Gary B. Tatterson

Publisher: N.A

ISBN: 9780972663519

Category: Technology & Engineering

Page: 392

View: 2972

Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Scale-up

Modellübertragung in der Verfahrenstechnik

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527660461

Category: Science

Page: 295

View: 2986

Die Übertagung von Verfahren aus dem Labor-bzw. dem Techni-kumsmaßstab in den industriellen maßstab einer Produktiosanlage ist eine der wichtigsten ingenieurstechnischen Aufgaben in der chemischen Industrie. Die einzige zuverlässige Methode dazu basiert auf der Darstellung von Versuchsergebnissen im zutreffenden dimensions-analytischen Raum, der sich als maßstabsinvariant erweist. Das Buch ist in zwei Teile gegliedert: In der ersten Hälfte werden die vertiefte mathematische Vorkenntnisse dieses Themengebiet näherzubringen. Diskutiert werden die Grundlagen der Dimensionsanalyse, die Behandlung von temperaturabhängigen und von rheologischen Stoffwerten und die Modellübertragung bei Nichtverfügbarkeit von Modellstoffsystemen, sowie bei partieller Ähnlichkeit/ All dies wird dem leser anhand von 20 modernen Beispielen aus der heutigen verfahrenstechnischcen Praxis illustriert, der sich mit 25 in dieser Auflage neu hinzugekommenen Übungsaufgaben sein Verständnis aktive erarbeiten und anhand der Lösungen kontrollieren kann. Im zweitem Teil des Buches werden die einzelnen verfahrenstechnischen Grundoperationen aus den Bereichen mechanische, thermische und chemische Verfahrenstechnik aus der Sicht der Dimensionsanalyse und der Modellübertragung beispielhaft behandelt, und es werden für jede Operation die Maßstabsübertragungsregeln vorgestellt und diskutiert. Das vorliegende Buch wendet sich dementsprechend an Studenten wie auch bereits auf dem gebiet tätige Ingenieure, Chemiker und Verfahrenstechniker.

Process Scale Bioseparations for the Biopharmaceutical Industry

Author: Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam

Publisher: CRC Press

ISBN: 1420016024

Category: Science

Page: 575

View: 793

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules. Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends. Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.

Scaling Up

Skalieren auch Sie! Weshalb es einige Unternehmen packen… und warum andere stranden

Author: Verne Harnish

Publisher: Masterhouse GmbH

ISBN: 3981801709

Category: Business & Economics

Page: 336

View: 735

Es ist über ein Jahrzehnt her, dass Verne Harnish Bestseller Mastering the Rockefeller Habits in der ersten Auflage erschien. Scaling Up ist die erste große Neubearbeitung dieses Business-Klassikers, in dem praktische Tools und Techniken für das Wachstum zum branchenführenden Unternehmen vorgestellt werden. Dieses Buch wurde geschrieben, damit jeder – vom einfachen bis zum leitenden Angestellten – gleichermaßen zum Wachstum seines Business beträgt. Scaling Up konzentriert sich auf die vier Haupt-Entscheidungsbereiche, die jedes Unternehmen angehen muss: People, Strategy, Execution und Cash. Das Buch beinhaltet eine Reihe von neuen ganzseitigen Arbeits-Tools, darunter der aktualisierte One-Page Strategic Plan und die Rockefeller Habits Checklist™, die bereits von mehr als 40.000 Firmen in aller Welt für ein erfolgreiches Scaling Up verwendet wurden. Viele von ihnen schafften ein Wachstum auf $10 Millionen, $100 Millionen oder gar $1 Milliarde und mehr – und konnten den Aufstieg sogar genießen! Verne Harnish hat bereits in viele Scaleups investiert.

Handbook of Industrial Mixing

Science and Practice

Author: Edward L. Paul,Victor A. Atiemo-Obeng,Suzanne M. Kresta

Publisher: John Wiley & Sons

ISBN: 0471451444

Category:

Page: 1440

View: 3918

Handbook of Industrial Mixing will explain the difference and usesof a variety of mixers including gear mixers, top entry mixers,side entry mixers, bottom entry mixers, on-line mixers, andsubmerged mixers The Handbook discusses the trade-offs amongvarious mixers, concentrating on which might be considered for aparticular process. Handbook of Industrial Mixing explainsindustrial mixers in a clear concise manner, and also: * Contains a CD-ROM with video clips showing different type ofmixers in action and a overview of their uses. * Gives practical insights by the top professional in thefield. * Details applications in key industries. * Provides the professional with information he did receive inschool

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527607765

Category: Science

Page: 296

View: 9421

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Industrial Chemistry Case Studies

Industrial Processes in the 1990s

Author: Ted Lister

Publisher: Royal Society of Chemistry

ISBN: 9780854049257

Category: Education

Page: 185

View: 1688

Intended primarily for post-16 students and their teachers, this book presents material on a variety of aspects of the UK chemical and pharmaceutical industries in the late 1990s.

Scale-up of Liposome Manufacturing

Combining High Pressure Liposome Extrusion with Drying Technologies

Author: Michael Wiggenhorn

Publisher: Cuvillier Verlag

ISBN: 3867275432

Category:

Page: 220

View: 9118

Science, Agriculture, and Research

A Compromised Participation?

Author: William Buhler

Publisher: Earthscan

ISBN: 1849772487

Category: Reference

Page: 176

View: 7659

Research is never free of pressures and constraints and to understand its results properly these have to be assessed and analyzed. In agriculture, research into biotechnology and GMOs, as well as pesticides and herbicides, is big business - agribusiness. This book looks at the crucial roles of funding and the political context on the research agenda and its results in agricultural development. It provides a critical evaluation of the participatory methods now widely used and explores the ways in which research into biotechnology have reflected the interests of the various parties involved.

Electro-Fenton Process

New Trends and Scale-Up

Author: Minghua Zhou,Mehmet A. Oturan,Ignasi Sirés

Publisher: Springer

ISBN: 9811064067

Category: Science

Page: 430

View: 6736

This volume discusses the theoretical fundamentals and potential applications of the original electro-Fenton (EF) process and its most innovative and promising versions, all of which are classified as electrochemical advanced oxidation processes. It consists of 15 chapters that review the latest advances and trends, material selection, reaction and reactor modeling and EF scale-up. It particularly focuses on the applications of EF process in the treatment of toxic and persistent organic pollutants in water and soil, showing highly efficient removal for both lab-scale and pre-pilot setups. Indeed, the EF technology is now mature enough to be brought to market, and this collection of contributions from leading experts in the field constitutes a timely milestone for scientists and engineers.

Process Chemistry in the Pharmaceutical Industry, Volume 2

Challenges in an Ever Changing Climate

Author: Kumar Gadamasetti,Tamim Braish

Publisher: CRC Press

ISBN: 9781420008357

Category: Science

Page: 520

View: 742

As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explores novel applications of synthetic, physical, and analytical chemistry in drug discovery and development. It offers an accurate depiction of the most up-to-date process research and development methods applied to synthesis, clinical trials, and commercializing drug candidates. The second installment in this progressive series, this volumereviews the latest breakthroughs to advance process chemistry, including asymmetric synthesis, crystallization, morphology, enzymatic intervention, green chemistry, macromolecules (monoclonal antibodies, biological molecules, polymers), enantioselectivity, organometallic chemistry, process analytical tools, chemical engineering controls, regulatory compliance, and outsourcing/globalization. It explores new approaches to synthetic processes, examines the latest safety methods and experiment design, and suggests realistic solutions to problems encountered in manufacturing and process development. Significant topics include atom economy, ease of synthesis, instrumentation, automization, quality control, cost considerations, green practices, and future trends. Jointly edited by the founder/president of Delphian Pharmaceuticals and the director of Chemical R&D at Pfizer, this book brings together contributions byreputed scientists, technologists, engineers, and professors from leading academic institutions, such as the Imperial College, UK, the University of Tokyo, ETH, Switzerland, the International University at Bermen, Germany, and the University of Connecticut, USA, and from principal pharmaceutical companies that include Merck, Bristol Myers Squibb, Pfizer, Novartis, Eli Lilly, Astrazeneca and DSM.

Industrial Drying of Foods

Author: Christopher G J Baker

Publisher: Springer Science & Business Media

ISBN: 9780751403848

Category: Cooking

Page: 309

View: 5226

Drying is fundamental step in the maufacture of many foods. Although its primary function is to remove appropriate quantities of moisture it is, in many cases, also responsible for imparting the characteristic qualities that distinguish one product from another. This book provides a fundamental understanding of moisture transport in the drying of foods and of the physical and chemical changes that occur during drying. A comprehensive description and assessment of the different types of dryers available to the industry are given and factors effecting the operation, control and selection of dryers are described. The combination of practical information supported by relevant theory makes this an essential volume for industrial food engineers, those involved in equipment manufacture, process plant design and new product development in all food sectors where dried foods are used. It will also be of interest to academic researchers in this aspect of food engineering.