Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier

ISBN: 0444627391

Category: Technology & Engineering

Page: 112

View: 5798

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Industrial Process Scale-Up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier Science Limited

ISBN: 9780444627261

Category: Science

Page: 116

View: 6495

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 352763715X

Category: Science

Page: 370

View: 9404

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Pharmaceutical Process Scale-Up, Second Edition

Author: Michael Levin

Publisher: Informa Health Care

ISBN: 9781574448764

Category: Medical

Page: 576

View: 8666

Keeping pace with the increased influence of PAT in the pharmaceutical industry, this completely updated reference spans the latest research and regulations, technologies, and expert solutions for every significant aspect of pharmaceutical process scale-up-clearly introducing readers to the theoretical concept of dimensional analysis to quantify similar processes on varying scales.

Scale-up Methodology for Chemical Processes

Author: Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier

Publisher: Editions TECHNIP

ISBN: 9782710806462

Category: Technology & Engineering

Page: 240

View: 9102

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Scaleup and Design of Industrial Mixing Processes

Author: Gary B. Tatterson

Publisher: N.A

ISBN: 9780972663519

Category: Technology & Engineering

Page: 392

View: 6683

Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Pharmaceutical Process Scale-Up

Author: Michael Levin

Publisher: CRC Press

ISBN: 082474196X

Category: Medical

Page: 584

View: 6237

Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling, granulation and drying, fluid bed applications, compaction and tableting, and film coating and regulatory requirements for scale-up and postapproval changes. Drawing on the experience of twenty contributing researchers, the book employs dimensional analysis as a unified scientific approach to quantify similar processes on different scales.

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Elsevier

ISBN: 0080514480

Category: Science

Page: 354

View: 319

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

Chemical Projects Scale Up

How to go from Laboratory to Commercial

Author: Joe M. Bonem

Publisher: Elsevier

ISBN: 0128137282

Category: Technology & Engineering

Page: 232

View: 7661

Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527607765

Category: Science

Page: 296

View: 6507

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Process Scale Bioseparations for the Biopharmaceutical Industry

Author: Abhinav A. Shukla,Mark R. Etzel,Shishir Gadam

Publisher: CRC Press

ISBN: 1420016024

Category: Science

Page: 575

View: 4421

The biopharmaceutical industry has become an increasingly important player in the global economy, and the success of these products depends on the development and implementation of cost-effective, robust and scaleable production processes. Bioseparations-also called downstream processing- can be a key source of competitive advantageto biopharmaceutical developers. Process Scale Bioseparations for the Biopharmaceutical Industry brings together scientific principles, empirical approaches, and practical considerations for designing industrial downstream bioprocesses for various classes of biomolecules. Using clear language along with numerous case studies, examples, tables, flow charts, and schematics, the book presents perspectives from experienced professionals involved in purification processes and industrial downstream unit operations. The authors provide useful experimental design strategies and guidelines for developing application-specific process scale bioseparations. Chapter topics include harvest by centrifugation and filtration, expanded bed chromatography, protein refolding, modes of preparative chromatography, methodologies for resin screening, membrane chromatography, protein crystallization, viral filtration, ultrafiltration/diafiltration, implementing post-approval downstream process changes for an antibody product, and future trends. Ideal for both new and experienced scientists in the biopharmaceutical industry and students, Process Scale Bioseparations for the Biopharmaceutical Industry is a comprehensive resource for all topics relevant to industrial process development.

Process Plant Design

Heinemann Chemical Engineering Series

Author: J R Backhurst,J H Harker

Publisher: Butterworth-Heinemann

ISBN: 1483162389

Category: Science

Page: 414

View: 671

Process Plant Design provides an introduction to the basic principles of plant design and shows how the fundamentals of design can be blended with commercial aspects to produce a final specification; how textbook parameters can be applied to the solution of real problems; and how training in chemical engineering can best be utilized in the industrial sphere. It has been assumed that the reader knows how to calculate a heat transfer coefficient and the height of an absorber, for example, and the bulk of the book is concerned with the translation of such parameters into plant items which are ultimately linked into the production unit. The book follows a fairly logical sequence in which flowsheets, heat and mass balances, for example, are considered before attention is paid to the design of plant items, exchangers, columns, and so on. Because of the vital role of economics in any design function, costing is dealt with early in the book and the principles further developed as appropriate. Rarely is the plant designer concerned with the design of smaller and standard items of equipment, and hence considerable emphasis is placed on the selection of such items. This section may prove of particular value to the engineer in industry, especially if he has not the backing of comprehensive technical manuals produced by the larger companies. Finally, an attempt is made to draw together the many facets of equipment design into one specification for the complete plant, and the many aspects relating to the completed unit are introduced in a final section.

Solid/Liquid Separation

Scale-up of Industrial Equipment

Author: Stephen Tarleton,Richard Wakeman

Publisher: Elsevier

ISBN: 9780080551289

Category: Technology & Engineering

Page: 454

View: 2175

This book identifies test procedures used within sectors of the solid/liquid separation equipment industry, providing practical explanations for test data and their uses when faced with a new application to assess. With a strong practical emphasis, this book is ideal for use as a reference text for engineers concerned with applications evaluation of equipment or its scale-up. This book forms part of a five-volume set on all aspects of filtration and separation processes. One other volume is currently available from the set: Wakeman & Tarleton: Solid/Liquid Separation: Principles of Industrial Filtration. This book... •Provides guidance on how to tackle practical solid/liquid separation problems in an industrial setting •Shows how to plan, conduct and interpret experiments •Details test procedures, types of tests and how to interpret results when assessing a new application •Strong emphasis on current industrial practice •Provides a practical account which will help lead to the best use of appropriate equipment yielding optimal results ·Provides guidance on how to tackle practical solid/liquid separation problems in an industrial setting ·Shows how to plan, conduct and interpret experiments ·Details test procedures, types of tests and how to interpret results when assessing a new application ·Strong emphasis on current industrial practice ·Provides a practical account which will help lead to the best use of appropriate equipment yielding optimal results

Industrial Catalytic Processes for Fine and Specialty Chemicals

Author: Sunil S Joshi,Vivek V. Ranade

Publisher: Elsevier

ISBN: 0128016701

Category: Science

Page: 782

View: 9589

Industrial Catalytic Processes for Fine and Specialty Chemicals provides a comprehensive methodology and state-of-the art toolbox for industrial catalysis. The book begins by introducing the reader to the interesting, challenging, and important field of catalysis and catalytic processes. The fundamentals of catalysis and catalytic processes are fully covered before delving into the important industrial applications of catalysis and catalytic processes, with an emphasis on green and sustainable technologies. Several case studies illustrate new and sustainable ways of designing catalysts and catalytic processes. The intended audience of the book includes researchers in academia and industry, as well as chemical engineers, process development chemists, and technologists working in chemical industries and industrial research laboratories. Discusses the fundamentals of catalytic processes, catalyst preparation and characterization, and reaction engineering Outlines the homogeneous catalytic processes as they apply to specialty chemicals Introduces industrial catalysis and catalytic processes for fine chemicals Includes a number of case studies to demonstrate the various processes and methods for designing green catalysts

Food Processing Operations and Scale-up

Author: Kenneth J. Valentas,J. Peter Clark,Leon Levin

Publisher: CRC Press

ISBN: 9780824782795

Category: Technology & Engineering

Page: 408

View: 5473

Intended for students and practitioners who have a basic education in chemical engineering or food science. Contains basic information in each area and describes some of the fundamental ideas of processing development and design. Examines the food industry structure, how it works, consumer products,

Biopharmaceutical Processing

Development, Design, and Implementation of Manufacturing Processes

Author: Gunter Jagschies,Eva Lindskog,Karol Lacki,Parrish M. Galliher

Publisher: Elsevier

ISBN: 0128125527

Category: Technology & Engineering

Page: 1308

View: 2429

Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry. The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry. Offers a comprehensive, go-to reference for daily work decisions Covers both upstream and downstream processes Includes case studies that emphasize financial outcomes Presents summaries, decision grids, graphs and overviews for quick reference

Protein Chromatography

Process Development and Scale-Up

Author: Giorgio Carta,Alois Jungbauer

Publisher: John Wiley & Sons

ISBN: 3527318194

Category: Science

Page: 364

View: 6698

With its focus on process development and large-scale bioseparation tasks, this is tailor-made reading for the professional bioengineer in both the biotech and pharmaceutical industries. Following a tried-and-tested concept, this guide has been developed over several years in training courses for biotech and chemical engineers in Europe and the U.S. The first part deals with the theory, introducing chromatography and its dynamics, as well as discussing mass transfer and dispersion effects. The second part then goes on to cover equipment and protocols, determining the retention factor and HETP from isocratic and elution experiments, as well as the mass transfer and intraparticle diffusivity from batch and shallow-bed adsorption experiments.

Asymmetric Catalysis on Industrial Scale

Challenges, Approaches and Solutions

Author: Hans Ulrich Blaser,Hans-Jürgen Federsel

Publisher: John Wiley & Sons

ISBN: 3527642161

Category: Science

Page: 580

View: 2144

This second edition of the pioneering work on this hot topic captures the major trends and latest achievements in the art of asymmetric catalysis on an industrial scale. A number of completely new real-life case studies written by the world leaders in their respective areas provide a compact and qualified insight into this developing field. The resulting ready reference and handbook collates first-hand and valuable information within a context where it can be easily found. The high-quality contributions illustrate the relevant environments and situations, such as time pressure, how the catalytic step fits into the overall synthesis, or competition with other synthetic approaches, as well as the typical problems encountered in the various phases, including finding/developing the catalyst and optimization of the process or choice of equipment. Both successful and unsuccessful approaches to solve these problems are described.

Engineering for Sustainability

A Practical Guide for Sustainable Design

Author: Gerald Jonker,Jan Harmsen

Publisher: Elsevier

ISBN: 0444538461

Category: Science

Page: 110

View: 1067

Preface -- 1. Introduction -- 2. Setting up a design assignment -- 3. Structuring the sustainability context -- 4. Creating design solutions -- 5. Acquiring sustainable design competences.

The Pilot Plant Real Book

A Unique Handbook for the Chemical Process Industry

Author: Francis X. McConville

Publisher: Fxm Engineering & Design

ISBN: 9780972176927

Category: Science

Page: 320

View: 4501