Introduction to Genomics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0198754833

Category:

Page: 544

View: 6983

Our genome is the blueprint for our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. Yet it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on andoff in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How do we determine their function? And how do different genes form the regulatory networks that direct the processes of life? Introduction to Genomics is the most up-to-date and complete textbook for students approaching the subject for the first time. Lesk's engaging writing style brings a narrative to a disparate field of study and offers a fascinating insight into what can be revealed from the study of genomes. The bookcovers: the similarities and differences between organisms; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. The Online Resource Centre accompanying Introduction to Genomics features: For students: * Extensive and imaginative weblems (web-based problems) for each chapter designed to give you practice with the tools required for further study and research in the field* Hints and answers to end-of-chapter problems and exercises support your self-directed learning* Guided tour of websites and major archival databanks in genomics offer a wealth of resources to springboard your own research * Journal club: links to related research articles on topics covered in the book are paired with engaging questions to improve your interpretation of the primary literature* Rotating figures allow you to visualize complex structuresFor registered adopters: * Downloadable figures from the book.

Introduction to Genomics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0199564353

Category: Medical

Page: 397

View: 7202

Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genome structure and function means in terms of our future health and wellbeing.

Introduction to Genomics

Author: Arthur M. Lesk

Publisher: Oxford University Press, USA

ISBN: 9780199296958

Category: Medical

Page: 419

View: 4515

Our genome is the blueprint to our existence: it encodes all the information we need to develop from a single cell into a hugely complicated functional organism. But it is more than a static information store: our genome is a dynamic, tightly-regulated collection of genes, which switch on and off in many combinations to give the variety of cells from which our bodies are formed. But how do we identify the genes that make up our genome? How we determine their function? And how do different genes form the regulatory networks that direct the process of life? Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genomics means in terms of our future health and wellbeing. Covering the latest techniques that enable us to study the genome in ever-increasing detail, the book explores what the genome tells us about life at the level of the molecule, the cell, the organism, the ecosystem and the biosphere. Learning features throughout make this book the ideal teaching and learning tool: extensive end of chapter exercises and problems help the student to grasp fully the concepts being presented, while end of chapter WebLems (web-based problems) and lab assignments give the student the opportunity to engage with the subject in a hands-on manner. The field of genomics is enabling us to analyze life in more detail than ever before; Introduction to Genomics is the perfect guide to this enthralling subject. Online Resource Centre: - Figures from the book available to download, to facilitate lecture preparation - Answers to odd-numbered end of chapter exercises, and hints for solving end of chapter problems, to support self-directed learning - Library of web links, for rapid access to a wider pool of additional resources

Introduction to Genomics

Author: CTI Reviews

Publisher: Cram101 Textbook Reviews

ISBN: 1467255254

Category: Education

Page: 85

View: 7143

Facts101 is your complete guide to Introduction to Genomics. In this book, you will learn topics such as Evolution and Genomic Change, Mapping, Sequencing, Annotation, and Databases, Microarrays, and Proteomics plus much more. With key features such as key terms, people and places, Facts101 gives you all the information you need to prepare for your next exam. Our practice tests are specific to the textbook and we have designed tools to make the most of your limited study time.

An Introduction to Ecological Genomics

Author: Nico M. van Straalen,Dick Roelofs

Publisher: Oxford University Press

ISBN: 0199594686

Category: Science

Page: 363

View: 4713

The genomics revolution has expanded from its origins in molecular biology to impact upon every discipline in the life sciences, including ecology. This new edition incorporates a balance of plant, animal, and microbial examples, and continues to define the new and exciting field of ecological genomics.

Genomics and Bioinformatics

An Introduction to Programming Tools for Life Scientists

Author: Tore Samuelsson

Publisher: Cambridge University Press

ISBN: 1107008565

Category: Computers

Page: 338

View: 9292

A hands-on introduction to Unix, Perl and other bioinformatics tools using relevant and interesting molecular biology problems.

Introduction to Protein Science

Architecture, Function, and Genomics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0199541302

Category: Education

Page: 455

View: 493

Introduction to Protein Science provides a broad introduction to the contemporary study of proteins in health and disease, suitable for students on biological, biochemical, and biomedical degrees internationally. The book relates the study of proteins to the context of modern high-throughput data streams of genomics and proteomics.

Introduction to Evolutionary Genomics

Author: Naruya Saitou

Publisher: Springer Science & Business Media

ISBN: 1447153049

Category: Computers

Page: 461

View: 2839

This book is the first of its kind to explain the fundamentals of evolutionary genomics. The comprehensive coverage includes concise descriptions of a variety of genome organizations, a thorough discussion of the methods used, and a detailed review of genome sequence processing procedures. The opening chapters also provide the necessary basics for readers unfamiliar with evolutionary studies. Features: introduces the basics of molecular biology, DNA replication, mutation, phylogeny, neutral evolution, and natural selection; presents a brief evolutionary history of life from the primordial seas to the emergence of humans; describes the genomes of prokaryotes, eukaryotes, vertebrates, and humans; reviews methods for genome sequencing, phenotype data collection, homology searches and analysis, and phylogenetic tree and network building; discusses databases of genome sequences and related information, evolutionary distances, and population genomics; provides supplementary material at an associated website.

Introduction to Genomic Signal Processing with Control

Author: Aniruddha Datta,Edward R. Dougherty

Publisher: CRC Press

ISBN: 9781420006674

Category: Technology & Engineering

Page: 288

View: 348

Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks. The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms. The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state. Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering.

Exploring Personal Genomics

Author: Joel T. Dudley,Konrad J. Karczewski

Publisher: Oxford University Press

ISBN: 0199644489

Category: Medical

Page: 243

View: 9179

This book provides a novel inquiry-based approach to understanding and interpreting the practical, medical, and societal aspects of personal genomic information. It opens with an introduction to genomics and the issues surrounding the use of genomic data, and then discusses the potential applications of this data using real examples and data sets.

Introduction to Computational Genomics

A Case Studies Approach

Author: Nello Cristianini,Matthew W. Hahn

Publisher: Cambridge University Press

ISBN: 1139460153

Category: Computers

Page: N.A

View: 9504

Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.

Introduction to Biological Networks

Author: Alpan Raval,Animesh Ray

Publisher: CRC Press

ISBN: 1420010360

Category: Mathematics

Page: 335

View: 4205

The new research area of genomics-inspired network biology lacks an introductory book that enables both physical/computational scientists and biologists to obtain a general yet sufficiently rigorous perspective of current thinking. Filling this gap, Introduction to Biological Networks provides a thorough introduction to genomics-inspired network biology for physical scientists and biologists involved in interdisciplinary research. The book focuses on the concept of molecular and genetic interaction networks as a paradigm for interpreting the complexity of molecular biology at a genomic scale. The authors describe the experimental methods used to discover and test networks of interaction among biological molecules. They also present computational methods for predicting the interaction networks, discuss general mechanisms of network formation and evolution, and explore the application of network approaches to important problems in biology and medicine. With many examples throughout and clear explanations of key concepts, this book is the first to offer a broad treatment of genomics-inspired network biology with sufficient mathematical and biological rigor. It gives readers a conceptual understanding of this burgeoning scientific field.

From Genes to Genomes

Concepts and Applications of DNA Technology

Author: Jeremy W. Dale,Malcolm von Schantz,Nicholas Plant

Publisher: John Wiley & Sons

ISBN: 1119954274

Category: Science

Page: 408

View: 661

The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.

Introduction to Bioinformatics

Author: Arthur Lesk

Publisher: Oxford University Press

ISBN: 0199651566

Category: Science

Page: 371

View: 3148

Lesk provides an accessible and thorough introduction to a subject which is becoming a fundamental part of biological science today. The text generates an understanding of the biological background of bioinformatics.

Routledge Handbook of Genomics, Health and Society

Author: Sahra Gibbon,Barbara Prainsack,Stephen Hilgartner,Janelle Lamoreaux

Publisher: Routledge

ISBN: 1315451670

Category: Science

Page: 316

View: 3973

The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences. Building from and extending the first Routledge Handbook of Genetics and Society, the book offers a comprehensive introduction to pivotal themes within the field, an overview of the current state of the art knowledge on genomics, science and society, and an outline of emerging areas of research. Key themes addressed include the way genomic based DNA technologies have become incorporated into diverse arenas of clinical practice and research whilst also extending beyond the clinic; the role of genomics in contemporary ‘bioeconomies’; how challenges in the governance of medical genomics can both reconfigure and stabilise regulatory processes and jurisdictional boundaries; how questions of diversity and justice are situated across different national and transnational terrains of genomic research; and how genomics informs – and is shaped by – developments in fields such as epigenetics, synthetic biology, stem cell, microbial and animal model research. Presenting cutting edge research from leading social science scholars, the Handbook provides a unique and important contribution to the field. It brings a rich and varied cross disciplinary social science perspective that engages with both the history and contemporary context of genomics and ‘post-genomics’, and considers the now global and transnational terrain in which these developments are unfolding.

Computational Genome Analysis

An Introduction

Author: Richard C. Deonier,Simon Tavaré,Michael Waterman

Publisher: Springer Science & Business Media

ISBN: 9780387987859

Category: Computers

Page: 535

View: 9767

This book presents the foundations of key problems in computational molecular biology and bioinformatics. It focuses on computational and statistical principles applied to genomes, and introduces the mathematics and statistics that are crucial for understanding these applications. The book features a free download of the R software statistics package and the text provides great crossover material that is interesting and accessible to students in biology, mathematics, statistics and computer science. More than 100 illustrations and diagrams reinforce concepts and present key results from the primary literature. Exercises are given at the end of chapters.

Introduction to Computational Biology

Maps, Sequences and Genomes

Author: Michael S. Waterman

Publisher: CRC Press

ISBN: 1351437089

Category: Mathematics

Page: 448

View: 5032

Biology is in the midst of a era yielding many significant discoveries and promising many more. Unique to this era is the exponential growth in the size of information-packed databases. Inspired by a pressing need to analyze that data, Introduction to Computational Biology explores a new area of expertise that emerged from this fertile field- the combination of biological and information sciences. This introduction describes the mathematical structure of biological data, especially from sequences and chromosomes. After a brief survey of molecular biology, it studies restriction maps of DNA, rough landmark maps of the underlying sequences, and clones and clone maps. It examines problems associated with reading DNA sequences and comparing sequences to finding common patterns. The author then considers that statistics of pattern counts in sequences, RNA secondary structure, and the inference of evolutionary history of related sequences. Introduction to Computational Biology exposes the reader to the fascinating structure of biological data and explains how to treat related combinatorial and statistical problems. Written to describe mathematical formulation and development, this book helps set the stage for even more, truly interdisciplinary work in biology.

Bioinformatics and Functional Genomics

Author: Jonathan Pevsner

Publisher: John Wiley & Sons

ISBN: 1118581784

Category: Science

Page: 1160

View: 7309

Bioinformatics and Functional Genomics, Third Edition is the latest revision of this bestselling and indispensible text book. Thoroughly updated to encompass the latest advances in the field the book retains its broad and accessible approach. Divided into three parts the book deals first with bioinformatics, the use of computer databases and computer algorithms in the study of proteins and genes. The first section includes sequence alignment, database searches and phylogeny. The second section of the book focuses on functional genomics and includes approaches such as gene expression profiling and proteomics that are used to study cellular function. The final part of the book deals with genomics which is the study of the collection of DNA that comprises an organism, using the tools of bioinformatics. Bioinformatics and Functional Genomics, Third Edition will serve as an excellent single-source textbook for advanced undergraduate and beginning graduate-level courses in the biological sciences and computer sciences. It will also provide an essential resource for biologists in a broad variety of disciplines who use the tools of bioinformatics and genomics to study particular research problems; bioinformaticists and computer scientists who develop computer algorithms and databases; and medical researchers and clinicians who want to understand the genomic basis of viral, bacterial, parasitic, or other diseases.

Welcome to the Genome

A User's Guide to the Genetic Past, Present, and Future

Author: Rob DeSalle,Michael Yudell,American Museum of Natural History

Publisher: Wiley

ISBN: 9780471453314

Category: Science

Page: 240

View: 8704

A thrilling "user's guide" to the genomics era Welcome to the genome, the miraculous blueprint of your DNA, coiled tight as a spring in the nucleus of each cell of your body. If unwound, the DNA from just one cell, while only a molecule in width, would stretch six feet in length! The information stored in its double helix structure - three billion bits worth - could fill 142 Manhattan phone books. Yet far more amazing than these facts is the impact the study of genomics has had on so many areas of our lives. From the promise of personalized medicine and gene therapy to disputes over the safety of genetically modified (GM) foods, there is little doubt we are in the midst of the Genomic Revolution. Now how do we make sense of it all? Welcome to the Genome takes you right into the thick of today's most cutting-edge science and its far-reaching implications. Authors Rob DeSalle, who curated the highly successful Genomics Revolution exhibit at the American Museum of Natural History in New York, and Michael Yudell, Assistant Professor of Public Health at Drexel University, have written a book which clearly explains the ongoing saga of our attempts to understand the mystery of biology's Rosetta Stone and use its code to better our lives. This reader-friendly book employs an understandable style and eye-popping full-color illustrations to provide real insights into the complex science involved. It delves into the past discoveries that led to the sequencing of the human genome; it presents the challenges facing today's scientists and society and culture in general; and it considers the future possibilities of the developing genome era. Social issues, particularly questions of ethics, receive special attention, covering an important area too often overshadowed by science and technology. If the genome really is the book of life, then we have only just opened to the first of its many pages. Those who triumphantly claim DNA is destiny may have spoken too soon; it is far more likely today's discoveries will lead to insights yet to be imagined. A stirring and informative introduction to a scientific epic still unfolding, Welcome to the Genome is an essential guide for understanding - and participating in - the incredible explorations, discussions, and realizations of the Genomic Revolution.

Introduction to Marine Genomics

Author: J. Mark Cock,Kristin Tessmar-Raible,Catherine Boyen,Frédérique Viard

Publisher: Springer Science & Business Media

ISBN: 9789048186396

Category: Science

Page: 399

View: 535

Marine biology has always played an important role in biological research, being at the origin of many key advances. To a certain extent, the influence of marine biology on the biological sciences was overshadowed over a period of several years by the remarkable advances that were made using powerful model organisms from terrestrial environments. This situation is now changing again, however, due primarily to spectacular developments in genomic methodologies that have significantly accelerated research in a broad spectrum of marine biology disciplines ranging from biodiversity to developmental biology to biotechnology. The data generated by marine genomics projects have had an impact on questions as diverse as understanding planetary geochemical cycles, the impact of climate change on marine fauna and flora, the functioning of marine ecosystems, the discovery of new organisms and novel biomolecules, and investigation of the evolution of animal developmental complexity. This book represents the first attempt to document how genomic technologies are revolutionising these diverse domains of marine biology. Each chapter of this book looks at how these technologies are being employed in a specific domain of marine research and provides a summary of the major results obtained to date. The book as a whole provides an overview of marine genomics as a discipline and represents an ideal starting point for exploring this rapidly developing domain.