Mutants

On Genetic Variety and the Human Body

Author: Armand Marie Leroi

Publisher: Penguin

ISBN: 1101562765

Category: Science

Page: 448

View: 1534

Visit Armand Marie Leroi on the web: http://armandleroi.com/index.html Stepping effortlessly from myth to cutting-edge science, Mutants gives a brilliant narrative account of our genetic code and the captivating people whose bodies have revealed it—a French convent girl who found herself changing sex at puberty; children who, echoing Homer’s Cyclops, are born with a single eye in the middle of their foreheads; a village of long-lived Croatian dwarves; one family, whose bodies were entirely covered with hair, was kept at the Burmese royal court for four generations and gave Darwin one of his keenest insights into heredity. This elegant, humane, and engaging book “captures what we know of the development of what makes us human” (Nature).

Mutants

On the Form, Varieties and Errors of the Human Body

Author: Armand Marie Leroi

Publisher: HarperCollins UK

ISBN: 0006531644

Category: Abnormalities, Human

Page: 431

View: 1275

Stepping effortlessly from myth to molecular biology, this elegant, humane, and illuminating book explores the myths and fantasies associated with mutants and their critical link to human development.

Molecular Biology of the Cell

Author: Bruce Alberts

Publisher: Garland Science

ISBN: 1317563743

Category: Science

Page: 1464

View: 9486

As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Endless Forms Most Beautiful: The New Science of Evo Devo

Author: Sean B. Carroll

Publisher: W. W. Norton & Company

ISBN: 0393327795

Category: Science

Page: 350

View: 2269

Presents an introduction to evolutionary developmental biology which studies genes and their role in biological diversity and evolution.

The Rough Guide to the Brain

Author: Barry Gibb

Publisher: Penguin

ISBN: 140935993X

Category: Psychology

Page: 312

View: 1556

How does memory work? Are we addicted to television? What is Alzheimer's Disease? Can machines read our minds? The human brain, with all its inherent complexity, has taken on near mythical status. Its 100 billion nerve cells, forged by nature and refined over millions of years, allow humans the capacity to survive, create culture, love. Once an impenetrable grey mass, modern science is getting to grips with our brains at an unprecedented rate. We are moving from a time of anatomy, in which science did well to characterise the various regions of the brain, to a time in which we can observe thought processes in real time. We have entered a neural renaissance. The Rough Guide to the Brain is for anyone who's ever wanted to know more about how their brain and mind works - and what goes wrong when it doesn't. From how we evolved such an impressive organ to how it achieves the feat that is you. Including numerous insights from leaders in their fields, there's no better way to stimulate your grey matter.

Virolution

Author: Frank Ryan

Publisher: HarperCollins UK

ISBN: 0007545274

Category: Science

Page: 400

View: 9393

The extraordinary role of viruses in evolution and how this is revolutionising biology and medicine.

The Lagoon

How Aristotle Invented Science

Author: Armand Marie Leroi

Publisher: Penguin

ISBN: 0698170393

Category: Science

Page: 512

View: 6313

A brilliant study of Aristotle as biologist The philosophical classics of Aristotle loom large over the history of Western thought, but the subject he most loved was biology. He wrote vast volumes about animals. He described them, classified them, told us where and how they live and how they develop in the womb or in the egg. He founded a science. It can even be said that he founded science itself. In The Lagoon, acclaimed biologist Armand Marie Leroi recovers Aristotle’s science. He revisits Aristotle’s writings and the places where he worked. He goes to the eastern Aegean island of Lesbos to see the creatures that Aristotle saw, where he saw them. He explores Aristotle’s observations, his deep ideas, his inspired guesses—and the things he got wildly wrong. He shows how Aristotle’s science is deeply intertwined with his philosophical system and reveals that he was not only the first biologist, but also one of the greatest. The Lagoon is both a travelogue and a study of the origins of science. And it shows how a philosopher who lived almost two millennia ago still has so much to teach us today. From the Hardcover edition.

Life Unfolding

How the Human Body Creates Itself

Author: Jamie A. Davies

Publisher: Oxford University Press

ISBN: 0199673535

Category: Science

Page: 299

View: 6197

Tells the story of human development from egg to adult, showing how the understanding of how human beings come to be has been transformed in recent years.

Genetics of Bone Biology and Skeletal Disease

Author: Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi

Publisher: Academic Press

ISBN: 0128041986

Category: Medical

Page: 878

View: 7240

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Human Errors

A Panorama of Our Glitches, from Pointless Bones to Broken Genes

Author: Nathan H. Lents

Publisher: Houghton Mifflin Harcourt

ISBN: 1328974677

Category: Science

Page: 256

View: 552

An illuminating, entertaining tour of the physical imperfections that make us human We humans like to think of ourselves as highly evolved creatures. But if we are supposedly evolution’s greatest creation, why do we have such bad knees? Why do we catch head colds so often—two hundred times more often than a dog does? How come our wrists have so many useless bones? Why is the vast majority of our genetic code pointless? And are we really supposed to swallow and breathe through the same narrow tube? Surely there’s been some kind of mistake. As professor of biology Nathan H. Lents explains in Human Errors, our evolutionary history is nothing if not a litany of mistakes, each more entertaining and enlightening than the last. The human body is one big pile of compromises. But that is also a testament to our greatness: as Lents shows, humans have so many design flaws precisely because we are very, very good at getting around them. A rollicking, deeply informative tour of humans’ four billion year long evolutionary saga, Human Errors both celebrates our imperfections and offers an unconventional accounting of the cost of our success.

Time, Love , Memory

A Great Biologist and His Quest for the Origins of Behavior

Author: Jonathan Weiner

Publisher: Vintage

ISBN: 0804153361

Category: Biography & Autobiography

Page: 320

View: 3401

How much of our fate is decided before we are born? Which of our characteristics is inscribed in our DNA? Weiner brings us into Benzer's Fly Rooms at the California Institute of Technology, where Benzer, and his asssociates are in the process of finding answers, often astonishing ones, to these questions. Part biography, part thrilling scientific detective story, Time, Love, Memory forcefully demonstrates how Benzer's studies are changing our world view--and even our lives. Jonathan Weiner, winner of the Pulitzer Prize for The Beak of the Finch, brings his brilliant reporting skills to the story of Seymour Benzer, the Brooklyn-born maverick scientist whose study of genetics and experiments with fruit fly genes has helped revolutionize or knowledge of the connections between DNA and behavior both animal and human.

The Fifth Miracle

The Search for the Origin and Meaning of Life

Author: Paul Davies

Publisher: Simon and Schuster

ISBN: 1439126828

Category: Science

Page: 304

View: 8288

ARE WE ALONE IN THE UNIVERSE? In his latest far-reaching book, The Fifth Miracle, internationally acclaimed physicist and writer Paul Davies confronts one of science's great outstanding mysteries -- the origin of life. Three and a half billion years ago, Mars resembled Earth. It was warm and wet and could have supported primitive organisms. If life once existed on Mars, might it have originated there and traveled to Earth inside meteorites blasted into space by cosmic impacts? Davies builds on the latest scientific discoveries and theories to address the larger question: What, exactly, is life? Is it the inevitable by-product of physical laws, as many scientists maintain, or an almost miraculous accident? Are we alone in the universe, or will life emerge on all Earth-like planets? And if there is life elsewhere in the universe, is it preordained to evolve toward greater complexity and intelligence? On the answers to these deep questions hinges the ultimate purpose of mankind -- who we are and what our place might be in the unfolding drama of the cosmos.

Pathobiology of Human Disease

A Dynamic Encyclopedia of Disease Mechanisms

Author: N.A

Publisher: Elsevier

ISBN: 0123864577

Category: Medical

Page: 5000

View: 3717

Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

The Telomere Effect

A Revolutionary Approach to Living Younger, Healthier, Longer

Author: Dr. Elizabeth Blackburn,Dr. Elissa Epel

Publisher: Grand Central Publishing

ISBN: 1455587966

Category: Health & Fitness

Page: 302

View: 4499

NEW YORK TIMES BESTSELLER The revolutionary book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

Survival of the Sickest LP

Author: Sharon Moalem,Jonathan Prince

Publisher: Harper Collins

ISBN: 0061232963

Category: Medical

Page: 372

View: 7935

Invites readers to change their perceptions about illness in order to understand disease as an essential component of the evolutionary process, citing the role of such malaises as diabetes, STDs, and the Avian Bird Flu in protecting the survival of the human race. (Health & Fitness)

Billions & Billions

Thoughts on Life and Death at the Brink of the Millennium

Author: Carl Sagan

Publisher: Ballantine Books

ISBN: 0307801020

Category: Science

Page: 320

View: 4191

In the final book of his astonishing career, Carl Sagan brilliantly examines the burning questions of our lives, our world, and the universe around us. These luminous, entertaining essays travel both the vastness of the cosmos and the intimacy of the human mind, posing such fascinating questions as how did the universe originate and how will it end, and how can we meld science and compassion to meet the challenges of the coming century? Here, too, is a rare, private glimpse of Sagan's thoughts about love, death, and God as he struggled with fatal disease. Ever forward-looking and vibrant with the sparkle of his unquenchable curiosity, Billions & Billions is a testament to one of the great scientific minds of our day. From the Trade Paperback edition.

Metabolic Diseases

Foundations of Clinical Management, Genetics, and Pathology

Author: E. Gilbert-Barness,L.A. Barness,P.M. Farrell

Publisher: IOS Press

ISBN: 1614997187

Category: Medical

Page: 960

View: 9123

The 2nd Edition of Metabolic Diseases provides readers with a completely updated description of the Foundations of Clinical Management, Genetics, and Pathology. A distinguished group of 31 expert authors has contributed 25 chapters as a tribute to Enid Gilbert-Barness and the late Lewis Barness--- both pioneers in this topic. Enid’s unique perspectives on the pathology of genetic disorders and Lew’s unsurpassed knowledge of metabolism integrated with nutrition have inspired the contributors to write interdisciplinary descriptions of generally rare, and always challenging, hereditary metabolic disorders. Discussions of these interesting genetic disorders are organized in the perspective of molecular abnormalities leading to morphologic disturbances with distinct pathology and clinical manifestations. The book emphasizes recent advances such as development of improved diagnostic methods and discovery of new, more effective therapies for many of the diseases. It includes optimal strategies for diagnosis and information on access to specialized laboratories for specific testing. The target audience is a wide variety of clinicians, including pediatricians, neonatologists, obstetricians, maternal-fetal specialists, internists, pathologists, geneticists, and laboratorians engaged in prenatal and/or neonatal screening. In addition, all scientists and health science professionals interested in metabolic diseases will find the comprehensive, integrated chapters informative on the latest discoveries. It is our hope that the 2nd Edition will open new avenues and vistas for our readers and that they will share with us the interest, excitement and passion of the research into all these challenging disorders.

The Human Animal

Author: Weston La Barre

Publisher: N.A

ISBN: N.A

Category: Anthropology

Page: 371

View: 2459

Gulliver in the Land of Giants

A Critical Biography and the Memoirs of the Celebrated Dwarf Joseph Boruwlaski

Author: Anna Grześkowiak-Krwawicz

Publisher: Ashgate Publishing, Ltd.

ISBN: 1409420345

Category: Biography & Autobiography

Page: 155

View: 3301

Polish-born Józef Boruwlaski was the most famous dwarf of the Enlightenment age. He travelled extensively throughout Europe, appearing and performing at royal courts and salons, before settling in Durham in his later life until his death at the age of 97. His memoirs, published in a bilingual (French and English) version in 1788, show him to have been an intelligent observer of the world he inhabited and explored. The life story of this miniature gentleman is not only interesting in its own right, but also offers a new perspective on the culture of the Enlightenment.

Incognito

The Secret Lives of the Brain

Author: David Eagleman

Publisher: Vintage

ISBN: 9780307379788

Category: Psychology

Page: 288

View: 4572

If the conscious mind—the part you consider to be you—is just the tip of the iceberg, what is the rest doing? In this sparkling and provocative new book, the renowned neuroscientist David Eagleman navigates the depths of the subconscious brain to illuminate surprising mysteries: Why can your foot move halfway to the brake pedal before you become consciously aware of danger ahead? Why do you hear your name being mentioned in a conversation that you didn’t think you were listening to? What do Ulysses and the credit crunch have in common? Why did Thomas Edison electrocute an elephant in 1916? Why are people whose names begin with J more likely to marry other people whose names begin with J? Why is it so difficult to keep a secret? And how is it possible to get angry at yourself—who, exactly, is mad at whom? Taking in brain damage, plane spotting, dating, drugs, beauty, infidelity, synesthesia, criminal law, artificial intelligence, and visual illusions, Incognito is a thrilling subsurface exploration of the mind and all its contradictions. From the Hardcover edition.