Pilot Plants and Scale-up of Chemical Processes II

Author: William Hoyle

Publisher: N.A

ISBN: 9780854047192

Category: Science

Page: 120

View: 4093

How do you translate bench chemistry into 10 -100 litre pilot plant scale? Drawing on the wealth of experience of its expert contributors, Pilot Plants and Scale-up of Chemical Processes II provides an insight into how methods, procedures and techniques can be optimised. Up-to-date and highly focused, this book addresses topics including the choice of phase-transfer catalyst, safe scale-up of both Grignard and organolithium reactions, and on-line techniques for examining crystallisation. Newly established collaborative industry/academia projects are discussed, along with other procedures that have a practical application in industry. As a source of innovative techniques and best current practice, this book is a must for process development and pilot plant chemists as well as chemical engineers.

Pilot Plants and Scale-up of Chemical Processes

Author: William Hoyle

Publisher: Royal Society of Chemistry

ISBN: N.A

Category: Science

Page: 97

View: 7756

One of the biggest challenges facing today's chemist and chemical engineer is the translation of bench chemistry to the pilot plant. This book provides expert insights into current best practice, and will prove an indispensable manual for all those involved in pilot plant design and scale-up implementation - process chemists, engineers and managers alike. The international expertise of the contributors covers a wide range of topics, and new material covered includes: the removal of heavy metals from effluent, heat flow calorimetry, low temperature processes, good manufacturing practice in pilot plants, design issues, the use of statistical methods in the running of pilot plants. Pilot Plants and Scale-Up of Chemical Processes is a must for all those who are, and wish to remain, expert in the field, providing for the first time in print, a comprehensive and unique perspective of pilot plant production.

Chemical Projects Scale Up

How to go from Laboratory to Commercial

Author: Joe M. Bonem

Publisher: Elsevier

ISBN: 0128137282

Category: Technology & Engineering

Page: 232

View: 7294

Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Scale-up Methodology for Chemical Processes

Author: Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier

Publisher: Editions TECHNIP

ISBN: 9782710806462

Category: Technology & Engineering

Page: 240

View: 2222

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 3527637168

Category: Science

Page: 370

View: 7522

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier

ISBN: 0444627391

Category: Technology & Engineering

Page: 112

View: 9644

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

The Pilot Plant Real Book

A Unique Handbook for the Chemical Process Industry

Author: Francis X. McConville

Publisher: Fxm Engineering & Design

ISBN: 9780972176927

Category: Science

Page: 320

View: 745

Scaling Chemical Processes

Practical Guides in Chemical Engineering

Author: Jonathan Worstell

Publisher: Butterworth-Heinemann

ISBN: 0128047690

Category: Technology & Engineering

Page: 186

View: 4000

Scaling Chemical Processes: Practical Guides in Chemical Engineering is one of a series of short texts that each provides a focused introductory view on a single subject. The full library spans the main topics in the chemical process industries for engineering professionals who require a basic grounding in various related topics. They are ‘pocket publications’ that the professional engineer can easily carry with them or access electronically while working. Each text is highly practical and applied, and presents first principles for engineers who need to get up to speed in a new area fast. The focused facts provided in each guide will help you converse with experts in the field, attempt your own initial troubleshooting, check calculations, and solve rudimentary problems. This book discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant. It bases scaling on similarity principles and uses dimensional analysis to derive the dimensionless parameters necessary to ensure a successful chemical process development program. This series is fully endorsed and co-branded by the IChemE, and they help to promote the series. Offers practical, short, concise information on the basics to help you get an answer or teach yourself a new topic quickly Includes industry examples to help you solve real world problems Provides key facts for professionals in convenient single subject volumes Discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527607765

Category: Science

Page: 296

View: 1036

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Practical Process Research and Development

Author: Neal G. Anderson

Publisher: Elsevier

ISBN: 0080514480

Category: Science

Page: 354

View: 2083

This book provides a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries. Process R&D describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. More people are being hired for work in this area as increasing numbers of drug candidates are identified through combinatorial chemistry and high-throughput screening. The book is directed to industrial (primarily organic) chemists, and academicians (particularly those involved in a growing number of start-up companies) and students who need insight into industrial process R&D. Current books do not describe hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." "Practical Process Research and Development" will be a valuable resource for researchers, managers, and graduate students. Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Includes over 100 tips for rapid process development Presents guidelines for implementing and troubleshooting processes

Chemical Process Equipment

Selection and Design

Author: James R. Couper,W. Roy Penney,James R. Fair, PhD

Publisher: Elsevier

ISBN: 0123972361

Category: Technology & Engineering

Page: 864

View: 7774

Chemical Process Equipment is a results-oriented reference for engineers who specify, design, maintain or run chemical and process plants. This book delivers information on the selection, sizing and operation of process equipment in a format that enables quick and accurate decision making on standard process and equipment choices, saving time, improving productivity, and building understanding. Coverage emphasizes common real-world equipment design rather than experimental or esoteric and focuses on maximizing performance. Legacy reference for chemical and related engineers who work with vendors to design, specify and make final equipment selection decisions Copious examples of successful applications, with supporting schematics and data to illustrate the functioning and performance of equipment Provides equipment rating forms and manufacturers’ data, worked examples, valuable shortcut methods, and rules of thumb to demonstrate and support the design process Heavily illustrated with line drawings and schematics to aid understanding, as well as graphs and tables to illustrate performance data

Chemical Engineering

Modelling, Simulation and Similitude

Author: Tanase Gh. Dobre,Jose G. Sanchez Marcano

Publisher: John Wiley & Sons

ISBN: 3527306072

Category: Science

Page: 568

View: 1479

A description of the use of computer aided modeling and simulation in the development, integration and optimization of industrial processes. The two authors elucidate the entire procedure step-by-step, from basic mathematical modeling to result interpretation and full-scale process performance analysis. They further demonstrate similitude comparisons of experimental results from different systems as a tool for broadening the applicability of the calculation methods. Throughout, the book adopts a very practical approach, addressing actual problems and projects likely to be encountered by the reader, as well as fundamentals and solution strategies for complex problems. It is thus equally useful for student and professional engineers and chemists involved in industrial process and production plant design, construction or upgrading.

Dimensional Analysis and Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: Springer Science & Business Media

ISBN: 3642766730

Category: Science

Page: 178

View: 748

Contemporary Chemical Process Engineers face complex design and research problems. Temperature-dependent physical properties and non-Newtonian flow behavior of substances in a process cannot be predicted by numerical mathematics. Scaling-up equipment for processing can often only be done with partial similarity methods. Standard textbooks often neglect topics like dimensional analysis, theory of similarity and scale-up. This book fills this gap! It is aimed both at university students and the process engineer. It presents dimensional analysis very comprehensively with illustrative examples of mechanical, thermal and chemical processes.

Encyclopedia of Chemical Processing

Author: Sunggyu Lee

Publisher: Taylor & Francis US

ISBN: 9780824755577

Category: Science

Page: 3289

View: 5960

Collecting information of vital interest to chemical, polymer, mechanical, electrical, and civil engineers, as well as chemists and chemical researchers, this "Encyclopedia "supplies nearly 350 articles on current design, engineering, science, and manufacturing practices-offering expertly written articles on technologies at the forefront of the field to maximize and enhance the research and production phases of current and emerging chemical manufacturing practices and techniques.

Pharmaceutical Process Development

Current Chemical and Engineering Challenges

Author: A. John Blacker,Mike T. Williams

Publisher: Royal Society of Chemistry

ISBN: 1849731462

Category: Science

Page: 354

View: 7540

This book is aimed at both graduates and postgraduates interested in a career in the pharmaceutical industry by informing them about the breadth of the work carried out in chemical research and development departments. It is also of great value to academics wishing to advise students on the merits of careers in chemical development over discovery.

Chemical Engineering in the Pharmaceutical Industry

R&D to Manufacturing

Author: David J. am Ende

Publisher: John Wiley & Sons

ISBN: 1118088107

Category: Technology & Engineering

Page: 904

View: 1378

This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical Industry. These include basic analytics for quantitation of reaction components– often skipped in ChE Reaction Engineering and kinetics books. In addition Chemical Engineering in the Pharmaceutical Industry introduces contemporary methods of data analysis for kinetic modeling and extends these concepts into Quality by Design strategies for regulatory filings. For the current professionals, in-silico process modeling tools that streamline experimental screening approaches is also new and presented here. Continuous flow processing, although mainstream for ChE, is unique in this context given the range of scales and the complex economics associated with transforming existing batch-plant capacity. The book will be split into four distinct yet related parts. These parts will address the fundamentals of analytical techniques for engineers, thermodynamic modeling, and finally provides an appendix with common engineering tools and examples of their applications.

Academia and Industrial Pilot Plant Operations and Safety

Author: Mary K. Moore,Elmer B. Ledesma

Publisher: Amer Chemical Society

ISBN: 9780841229600

Category: Science

Page: 128

View: 5199

This symposium series volume was developed in order to share papers presented at the 245th ACS National Meeting on the topic of pilot plants. The Industrial and Chemical Engineering, Applied Chemical Technology Subdivision hosted a one-day symposium for industry and academic researchers to present and share their work and best practices on operations and safety in pilot plant environments. Designing and building "pilot plants" can be a big challenge, and this volume outlines the proper operations needed to run a plant safely, in both academic and industrial environments. The book addresses issues like chemical separation, chemical reactions, waste generation, process controls, and spatial considerations, as well as safety precautions. It describes ways in which plant designers and contractors can consider ease of operation, maintenance, pinch-points, and sampling, among other aspects. In contrast to workers in large-scale facilities, pilot plant workers in both industry and academia are not only exposed to hazardous substances, they are exposed to such materials in a smaller setting and thus to potentially greater concentrations. This book brings together workers and researchers in pilot plant environments to present and share their best practices as regards operations and safety.

Fermentation and Biochemical Engineering Handbook

Author: Celeste M. Todaro,Henry C. Vogel

Publisher: William Andrew

ISBN: 1455730467

Category: Technology & Engineering

Page: 454

View: 5351

A complete reference for fermentation engineers engaged in commercial chemical and pharmaceutical production, Fermentation and Biochemical Engineering Handbook emphasizes the operation, development and design of manufacturing processes that use fermentation, separation and purification techniques. Contributing authors from companies such as Merck, Eli Lilly, Amgen and Bristol-Myers Squibb highlight the practical aspects of the processes—data collection, scale-up parameters, equipment selection, troubleshooting, and more. They also provide relevant perspectives for the different industry sectors utilizing fermentation techniques, including chemical, pharmaceutical, food, and biofuels. New material in the third edition covers topics relevant to modern recombinant cell fermentation, mammalian cell culture, and biorefinery, ensuring that the book will remain applicable around the globe. It uniquely demonstrates the relationships between the synthetic processes for small molecules such as active ingredients, drugs and chemicals, and the biotechnology of protein, vaccine, hormone, and antibiotic production. This major revision also includes new material on membrane pervaporation technologies for biofuels and nanofiltration, and recent developments in instrumentation such as optical-based dissolved oxygen probes, capacitance-based culture viability probes, and in situ real-time fermentation monitoring with wireless technology. It addresses topical environmental considerations, including the use of new (bio)technologies to treat and utilize waste streams and produce renewable energy from wastewaters. Options for bioremediation are also explained. Fully updated to cover the latest advances in recombinant cell fermentation, mammalian cell culture and biorefinery, along with developments in instrumentation Industrial contributors from leading global companies, including Merck, Eli Lilly, Amgen, and Bristol-Myers Squibb Covers synthetic processes for both small and large molecules