Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 3527637168

Category: Science

Page: 370

View: 2092

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Gravel Bed Rivers 6

From Process Understanding to River Restoration

Author: H. Habersack,H. Piegay,M. Rinaldi

Publisher: Elsevier

ISBN: 9780080553597

Category: Science

Page: 836

View: 3404

Based on the interdisciplinary approaches between earth science, engineering, physical geography, ecology and management, this text focuses on the theoretical questions, case-studies, challenges, and constraints taken from river restoration. It is illustrated with reports of new ground-breaking research covering spatial and temporal scales of physical processes in river catchments, coupling catchment and fluvial processes, grain dynamics and fluvial forms and on geo-ecology and restoration in mountain gravel-bed river environments. Each chapter includes discussions and comments providing experience and feedback from the fundamental research. This book covers scales of analysis for gravel-bed rivers, physics and modeling of processes at local and point scales, sediment delivery and storage, eco-geography and eco-hydraulics, and channel management and restoration. * Major topics in the field are presented by recognized scientific leaders * Chapters cover theories, practices, and methodologies in river management and restoration * Interdisciplinary approach includes case-studies on new, ground-breaking research

Groundwater-surface Water Interaction

Process Understanding, Conceptualization and Modelling

Author: Corinna Abesser,Thorsten Wagener,Gunnar Nuetzmann

Publisher: International Assn of Hydrological Sciences

ISBN: N.A

Category: Technology & Engineering

Page: 214

View: 8542

Selected papers from a symposium on A new Focus on Integrated Analysis of Groundwater-Surface Water Systems, held during the International Union of Geodesy and Geophysics XXIV General Assembly in Perugia, Italy, 11-13 July 2007.

Introduction of blockchain into the commodity trading process

Understanding the relationship between radical innovation and the value chain model in the case of commodity trading

Author: Christoph Ulbig

Publisher: diplom.de

ISBN: 3961162778

Category: Business & Economics

Page: N.A

View: 6440

Within the last years blockchain has become more in focus of the commodity trading sector because of its reputed potential. The characteristics of blockchain can be used to make it to an infrastructure technology. The trend toward the use of blockchain therefore furthers the optimization of the entire value chain and reduction of the friction costs within the trading process. To reduce friction costs and to make use of the characteristics of blockchain, the technology is being introduced as a radical innovation into the commodity trading value chain. The focus of this thesis is on the resulting effects on the value chain after implementation. The research is conducted in a qualitative way, with an inductive research approach. Data is collected in order to build the theory, and interviews are conducted using the Gioia methodology for data analysis. The findings indicate that the value chain as a source of competitive advantage is affected in an overall positive way for firms. Competitive advantage is supported by value-adding effects and cost reduction, which are both are enhanced through the use of blockchain. In addition, the results indicate that the competitive advantage of a company is also supported through power. The power that results from independence and control of data and information is enhanced by blockchain. It is therefore possible to conclude that the value chain of a company is positively affected by the radical innovation of blockchain. This leads to a greater competitive advantage for the company and positive performance in a competitive environment.

Natural Processes

Understanding Metaphysics Without Substance

Author: Andrew M. Winters

Publisher: Springer

ISBN: 3319675702

Category: Philosophy

Page: 124

View: 9710

In thinking about ontology as the study of being or what fundamentally exists, we can adopt an ontology that either takes substances or processes as primary. There are, however, both commonsense and naturalistic reasons for not fully adopting a substance ontology, which indicate that we ought to suspend judgment with respect to the acceptance of a substance ontology. Doing so allows room to further explore other ontologies. In this book, Andrew M. Winters argues that there are both commonsense and naturalistic reasons for further pursuing a process ontology. Adopting a process ontology allows us to overcome many of the difficulties facing a substance ontology while also accommodating many of the phenomenon that substance ontologies were appealed to for explanation. Given these reasons, we have both commonsense and naturalistic reasons for pursuing and developing a metaphysics without substance.

The Strategic Planning Process

Understanding Strategy in Global Markets

Author: Marios Katsioloudes,Arpi K Abouhanian

Publisher: Taylor & Francis

ISBN: 1317623177

Category: Business & Economics

Page: 392

View: 1811

Strategic management is a field that has diversity in approach and scope, but relative homogeneity in pedagogy. This book, a refreshed edition of its successful predecessor, brings something different to the field, by concisely introducing it with a focus on doing business in the Middle East and North Africa. Supplemented by online case studies and other resources, the reader is exposed to a plethora of concepts, theories, practical implications, and experiential exercises in the strategic management process. The updated text explores key regional issues, including the "Arab Spring", economic recession, corporate social responsibility, the role of women in business and the rise of emerging economies. The reader is encouraged to look at the world in light of the challenges many organizations are facing around the globe. Features like "Stop and Think Critically" and "Focus" points throughout each chapter encourage and inspire a thoughtful reading of the text. This is a book designed to aid undergraduate and graduate students, as well as managers in both for-profit and non-profit sectors. The authors guides the reader through both new and ongoing issues in the field of strategic management, and allow them to foster a greater understanding of this ever-developing field.

Heart Wisdom Process

Understanding and Healing the Subconscious

Author: Paul P. Wong

Publisher: Createspace Independent Publishing Platform

ISBN: 9781973911173

Category:

Page: 126

View: 2070

Takes a vast and highly complex subject about human suffering and psychology and breaks it into simple, straightforward, and easy-to-apply practical knowledge. It can immediately help you become aware of the deeper subconscious causes of your life challenges. Shares insights from a decade of Paul Wong's journey with his life's struggles, studying the healing arts, working with clients globally, traveling the world teaching seminars, and learning from spiritual masters in the ashrams of India. Offers an unique self-inquiry and self-healing process that can be used for almost any life challenge. The Heart Wisdom Process is a synthesis of ancient Eastern principles and thousands of hours of trials and tribulations over the years. It is a must read for anyone who loves personal development and anyone from the professional fields of coaching, mental health, traditional or alternative therapies.

Understanding Assessment in the Special Education Process

A Step-by-Step Guide for Educators

Author: Roger Pierangelo,George Giuliani

Publisher: Skyhorse Publishing, Inc.

ISBN: 1510701338

Category: Education

Page: 136

View: 2252

An ideal step-by-step reference for instructors who have not had specific training in assessing students with special needs, Understanding Assessment in the Special Education Process helps educators make the most effective use of available assessment options.

Shape Understanding System – Knowledge Implementation and Learning

Author: Zbigniew Les,Magdalena Les

Publisher: Springer

ISBN: 3642296971

Category: Computers

Page: 230

View: 4454

This book presents the selected results of research on the further development of the shape understanding system (SUS) described in our previous book titled “Shape Understanding System: the First Steps Toward the Visual Thinking Machines”. This is the second book that presents the results of research in the area of thinking and understanding carried out by authors in the newly founded the Queen Jadwiga Research Institute of Understanding. In this book, the new term knowledge implementation is introduced to denote the new method of the meaningful learning in the context of machine understanding. SUS ability to understand is related to the different categories of objects such as the category of visual objects, the category of sensory objects and the category of text objects. In this book, new terms and concepts are introduced in order to describe and explain some issues connected with SUS development. These terms are explained by referring to the content of our books and other our works rather than to existing literature in related areas of research. This book raises many questions that are discussed in the area of cognitive science or philosophy of mind.

Understanding HIV/AIDS Stigma

A Theoretical and Methodological Analysis

Author: Harriet Deacon

Publisher: HSRC Press

ISBN: 9780796921048

Category: AIDS (Disease)

Page: 104

View: 9174

At a time when alarming numbers of people with HIV/AIDS seek help under cover of darkness, deeply ashamed of their plight, it is crucial to find ways to better comprehend and address the specific nature of stigma around HIV/AIDS in southern Africa. Drawing on a cross-disciplinary, critical review of academic literature on this issue, the authors explore a range of theoretical approaches to conceptualizing stigma. Highlights the theoretical and methodological approaches that are most relevant in southern Africa.

Understanding Business

Processes

Author: David Barnes

Publisher: Psychology Press

ISBN: 9780415238618

Category: Business & Economics

Page: 225

View: 2793

Taking a systems perspective, this book enables the student to make sense of business behaviour by demonstrating how interrelated business processes determine the success of an organization.

Understanding Language Acquisition

The Framework of Learning

Author: Christina E. Erneling

Publisher: SUNY Press

ISBN: 9780791414613

Category: Language Arts & Disciplines

Page: 256

View: 6418

How is language acquisition possible? How is it that humans, within a few years of birth, can speak and understand language, transcending both its limited experience and biological limitations? In this challenge to the narrow confines of psychology and philosophy, Christina Erneling argues that language acquisition results from the interaction between linguistic creativity inherent in language and a biological and social framework of learning. Erneling explains and critically analyzes the idea that language acquisition requires a meaningful "language of thought," contrasting this with Wittgenstein's ideas on language and learning. Erneling shows that the assumptions in J. Fodor's development of Chomky's ideas into a theory of "language of thought" have significantly influenced developmental theories, yet fail to resolve the conflict between linguistic creativity and the necessity of a framework for learning. She argues that the later Wittgenstein was more concerned with the conditions of learning than is generally appreciated and shows how his remarks can be developed into an alternative approach to language learning. Understanding Language Acquisition has profound implications for evaluating hidden metatheoretical assumptions, as well as for empirical research and methods for teaching language and treating language disorders.

Understanding the Process of Aging

The Roles of Mitochondria: Free Radicals, and Antioxidants

Author: Lester Packer

Publisher: CRC Press

ISBN: 9780824717230

Category: Medical

Page: 384

View: 3312

This innovative reference explores a wide selection of topics associated with aging, providing a solid understanding of the significance and molecular basis of the aging process and charting the course of future research in the area. Stresses the interplay of mitochondria, mitochondrial DNA, oxidants, and antioxidants! Featuring the research of over 55 experts in the area, Understanding the Process of Aging covers the functions of nitric oxide and peroxynitrite in mitochondria integrates several views on the role of mitochondria in the development of apoptosis gives a quantitative analysis of mutations of mitochondrial DNA during human aging highlights mitochondrial free radical production introduces new roles of ubiquinone in mitochondrial functions offers new antioxidant-based complementary therapeutic strategies details aspects of intact cells and whole organisms in health and disease and more! Featuring over 1800 references, tables, drawings, and photographs, Understanding the Process of Aging benefits nutritionists and dieticians, geriatricians, cell and molecular biologists, chemists and biochemists, pharmacologists, biotechnologists, neurologists, cardiologists, oncologists, dermatologists, and graduate and medical school students in these disciplines.