Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 3527637168

Category: Science

Page: 370

View: 8406

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Groundwater-surface Water Interaction

Process Understanding, Conceptualization and Modelling

Author: Corinna Abesser,Thorsten Wagener,Gunnar Nuetzmann

Publisher: International Assn of Hydrological Sciences

ISBN: N.A

Category: Technology & Engineering

Page: 214

View: 5474

Selected papers from a symposium on A new Focus on Integrated Analysis of Groundwater-Surface Water Systems, held during the International Union of Geodesy and Geophysics XXIV General Assembly in Perugia, Italy, 11-13 July 2007.

Introduction of blockchain into the commodity trading process

Understanding the relationship between radical innovation and the value chain model in the case of commodity trading

Author: Christoph Ulbig

Publisher: diplom.de

ISBN: 3961162778

Category: Business & Economics

Page: N.A

View: 818

Within the last years blockchain has become more in focus of the commodity trading sector because of its reputed potential. The characteristics of blockchain can be used to make it to an infrastructure technology. The trend toward the use of blockchain therefore furthers the optimization of the entire value chain and reduction of the friction costs within the trading process. To reduce friction costs and to make use of the characteristics of blockchain, the technology is being introduced as a radical innovation into the commodity trading value chain. The focus of this thesis is on the resulting effects on the value chain after implementation. The research is conducted in a qualitative way, with an inductive research approach. Data is collected in order to build the theory, and interviews are conducted using the Gioia methodology for data analysis. The findings indicate that the value chain as a source of competitive advantage is affected in an overall positive way for firms. Competitive advantage is supported by value-adding effects and cost reduction, which are both are enhanced through the use of blockchain. In addition, the results indicate that the competitive advantage of a company is also supported through power. The power that results from independence and control of data and information is enhanced by blockchain. It is therefore possible to conclude that the value chain of a company is positively affected by the radical innovation of blockchain. This leads to a greater competitive advantage for the company and positive performance in a competitive environment.

Gravel Bed Rivers 6

From Process Understanding to River Restoration

Author: H. Habersack,H. Piegay,M. Rinaldi

Publisher: Elsevier

ISBN: 9780080553597

Category: Science

Page: 836

View: 4923

Based on the interdisciplinary approaches between earth science, engineering, physical geography, ecology and management, this text focuses on the theoretical questions, case-studies, challenges, and constraints taken from river restoration. It is illustrated with reports of new ground-breaking research covering spatial and temporal scales of physical processes in river catchments, coupling catchment and fluvial processes, grain dynamics and fluvial forms and on geo-ecology and restoration in mountain gravel-bed river environments. Each chapter includes discussions and comments providing experience and feedback from the fundamental research. This book covers scales of analysis for gravel-bed rivers, physics and modeling of processes at local and point scales, sediment delivery and storage, eco-geography and eco-hydraulics, and channel management and restoration. * Major topics in the field are presented by recognized scientific leaders * Chapters cover theories, practices, and methodologies in river management and restoration * Interdisciplinary approach includes case-studies on new, ground-breaking research

Business Process Modeling, Simulation and Design

Author: Manuel Laguna,Johan Marklund

Publisher: CRC Press

ISBN: 1351667254

Category: Business & Economics

Page: 526

View: 7422

Business Process Modeling, Simulation and Design, Third Edition provides students with a comprehensive coverage of a range of analytical tools used to model, analyze, understand, and ultimately design business processes. The new edition of this very successful textbook includes a wide range of approaches such as graphical flowcharting tools, cycle time and capacity analyses, queuing models, discrete-event simulation, simulation-optimization, and data mining for process analytics. While most textbooks on business process management either focus on the intricacies of computer simulation or managerial aspects of business processes, this textbook does both. It presents the tools to design business processes and management techniques on operating them efficiently. The book focuses on the use of discrete event simulation as the main tool for analyzing, modeling, and designing effective business processes. The integration of graphic user-friendly simulation software enables a systematic approach to create optimal designs.

Heart Wisdom Process

Understanding and Healing the Subconscious

Author: Paul P. Wong

Publisher: Createspace Independent Publishing Platform

ISBN: 9781973911173

Category:

Page: 126

View: 8382

Takes a vast and highly complex subject about human suffering and psychology and breaks it into simple, straightforward, and easy-to-apply practical knowledge. It can immediately help you become aware of the deeper subconscious causes of your life challenges. Shares insights from a decade of Paul Wong's journey with his life's struggles, studying the healing arts, working with clients globally, traveling the world teaching seminars, and learning from spiritual masters in the ashrams of India. Offers an unique self-inquiry and self-healing process that can be used for almost any life challenge. The Heart Wisdom Process is a synthesis of ancient Eastern principles and thousands of hours of trials and tribulations over the years. It is a must read for anyone who loves personal development and anyone from the professional fields of coaching, mental health, traditional or alternative therapies.

Understanding Assessment in the Special Education Process

A Step-by-Step Guide for Educators

Author: Roger Pierangelo,George Giuliani

Publisher: Corwin Press

ISBN: 1452239789

Category: Education

Page: 136

View: 4280

This handbook explains applicable federal regulations and clarifies the referral, assessment, and evaluation process that helps determine student eligibility for special education and related services.

Shape Understanding System – Knowledge Implementation and Learning

Author: Zbigniew Les,Magdalena Les

Publisher: Springer

ISBN: 3642296971

Category: Computers

Page: 230

View: 7422

This book presents the selected results of research on the further development of the shape understanding system (SUS) described in our previous book titled “Shape Understanding System: the First Steps Toward the Visual Thinking Machines”. This is the second book that presents the results of research in the area of thinking and understanding carried out by authors in the newly founded the Queen Jadwiga Research Institute of Understanding. In this book, the new term knowledge implementation is introduced to denote the new method of the meaningful learning in the context of machine understanding. SUS ability to understand is related to the different categories of objects such as the category of visual objects, the category of sensory objects and the category of text objects. In this book, new terms and concepts are introduced in order to describe and explain some issues connected with SUS development. These terms are explained by referring to the content of our books and other our works rather than to existing literature in related areas of research. This book raises many questions that are discussed in the area of cognitive science or philosophy of mind.

Understanding HIV/AIDS Stigma

A Theoretical and Methodological Analysis

Author: Harriet Deacon

Publisher: HSRC Press

ISBN: 9780796921048

Category: AIDS (Disease)

Page: 104

View: 6498

At a time when alarming numbers of people with HIV/AIDS seek help under cover of darkness, deeply ashamed of their plight, it is crucial to find ways to better comprehend and address the specific nature of stigma around HIV/AIDS in southern Africa. Drawing on a cross-disciplinary, critical review of academic literature on this issue, the authors explore a range of theoretical approaches to conceptualizing stigma. Highlights the theoretical and methodological approaches that are most relevant in southern Africa.

On-line Control of Metal Processing

Report of the

Author: National Research Council (U.S.). Committee on On-Line Control of Metal Processing,Diran Apelian

Publisher: National Academies

ISBN: N.A

Category: Artificial intelligence

Page: 102

View: 4500

Quality by Design for Biopharmaceuticals

Principles and Case Studies

Author: Anurag S. Rathore,Rohin Mhatre

Publisher: John Wiley & Sons

ISBN: 1118210913

Category: Science

Page: 312

View: 6527

The concepts, applications, and practical issues of Quality byDesign Quality by Design (QbD) is a new framework currently beingimplemented by the FDA, as well as EU and Japanese regulatoryagencies, to ensure better understanding of the process so as toyield a consistent and high-quality pharmaceutical product. QbDbreaks from past approaches in assuming that drug quality cannot betested into products; rather, it must be built into every step ofthe product creation process. Quality by Design: Perspectives and Case Studies presentsthe first systematic approach to QbD in the biotech industry. Acomprehensive resource, it combines an in-depth explanation ofbasic concepts with real-life case studies that illustrate thepractical aspects of QbD implementation. In this single source, leading authorities from thebiotechnology industry and the FDA discuss such topics as: The understanding and development of the product's criticalquality attributes (CQA) Development of the design space for a manufacturingprocess How to employ QbD to design a formulation process Raw material analysis and control strategy for QbD Process Analytical Technology (PAT) and how it relates toQbD Relevant PAT tools and applications for the pharmaceuticalindustry The uses of risk assessment and management in QbD Filing QbD information in regulatory documents The application of multivariate data analysis (MVDA) toQbD Filled with vivid case studies that illustrate QbD at work incompanies today, Quality by Design is a core reference forscientists in the biopharmaceutical industry, regulatory agencies,and students.

The Strategic Planning Process

Understanding Strategy in Global Markets

Author: Marios Katsioloudes,Arpi K Abouhanian

Publisher: Taylor & Francis

ISBN: 1317623177

Category: Business & Economics

Page: 392

View: 2047

Strategic management is a field that has diversity in approach and scope, but relative homogeneity in pedagogy. This book, a refreshed edition of its successful predecessor, brings something different to the field, by concisely introducing it with a focus on doing business in the Middle East and North Africa. Supplemented by online case studies and other resources, the reader is exposed to a plethora of concepts, theories, practical implications, and experiential exercises in the strategic management process. The updated text explores key regional issues, including the "Arab Spring", economic recession, corporate social responsibility, the role of women in business and the rise of emerging economies. The reader is encouraged to look at the world in light of the challenges many organizations are facing around the globe. Features like "Stop and Think Critically" and "Focus" points throughout each chapter encourage and inspire a thoughtful reading of the text. This is a book designed to aid undergraduate and graduate students, as well as managers in both for-profit and non-profit sectors. The authors guides the reader through both new and ongoing issues in the field of strategic management, and allow them to foster a greater understanding of this ever-developing field.

Understanding Language Acquisition

The Framework of Learning

Author: Christina E. Erneling

Publisher: SUNY Press

ISBN: 9780791414613

Category: Language Arts & Disciplines

Page: 256

View: 2052

How is language acquisition possible? How is it that humans, within a few years of birth, can speak and understand language, transcending both its limited experience and biological limitations? In this challenge to the narrow confines of psychology and philosophy, Christina Erneling argues that language acquisition results from the interaction between linguistic creativity inherent in language and a biological and social framework of learning. Erneling explains and critically analyzes the idea that language acquisition requires a meaningful "language of thought," contrasting this with Wittgenstein's ideas on language and learning. Erneling shows that the assumptions in J. Fodor's development of Chomky's ideas into a theory of "language of thought" have significantly influenced developmental theories, yet fail to resolve the conflict between linguistic creativity and the necessity of a framework for learning. She argues that the later Wittgenstein was more concerned with the conditions of learning than is generally appreciated and shows how his remarks can be developed into an alternative approach to language learning. Understanding Language Acquisition has profound implications for evaluating hidden metatheoretical assumptions, as well as for empirical research and methods for teaching language and treating language disorders.

Understanding Assessment and Evaluation in Early Childhood Education

Author: Dominic F. Gullo

Publisher: Teachers College Press

ISBN: 9780807745328

Category: Education

Page: 185

View: 3722

This bestselling book is still the best choice for helping early childhood teachers understand the process of assessment and evaluation to benefit young children. With the advent of the No Child Left Behind Act, testing, accountability, and standards are now pervasive throughout early childhood education. Completely revised to address the issues that have been raised by these new policies, the Second Edition features completely new chapters on: assessment of children from culturally and linguistically diverse backgrounds, addressing the new makeup of today's classroom; assessment of children with special needs, focusing on the relationship among assessment, curriculum, and instruction; and the addition of a helpful glossary of terms and an annotated listing of assessment instruments used in early childhood education.