Pilot Plants and Scale-up of Chemical Processes II

Author: William Hoyle

Publisher: N.A

ISBN: 9780854047192

Category: Science

Page: 120

View: 5917

How do you translate bench chemistry into 10 -100 litre pilot plant scale? Drawing on the wealth of experience of its expert contributors, Pilot Plants and Scale-up of Chemical Processes II provides an insight into how methods, procedures and techniques can be optimised. Up-to-date and highly focused, this book addresses topics including the choice of phase-transfer catalyst, safe scale-up of both Grignard and organolithium reactions, and on-line techniques for examining crystallisation. Newly established collaborative industry/academia projects are discussed, along with other procedures that have a practical application in industry. As a source of innovative techniques and best current practice, this book is a must for process development and pilot plant chemists as well as chemical engineers.

Pilot Plants and Scale-up of Chemical Processes

Author: William Hoyle

Publisher: Royal Society of Chemistry

ISBN: N.A

Category: Science

Page: 97

View: 2352

One of the biggest challenges facing today's chemist and chemical engineer is the translation of bench chemistry to the pilot plant. This book provides expert insights into current best practice, and will prove an indispensable manual for all those involved in pilot plant design and scale-up implementation - process chemists, engineers and managers alike. The international expertise of the contributors covers a wide range of topics, and new material covered includes: the removal of heavy metals from effluent, heat flow calorimetry, low temperature processes, good manufacturing practice in pilot plants, design issues, the use of statistical methods in the running of pilot plants. Pilot Plants and Scale-Up of Chemical Processes is a must for all those who are, and wish to remain, expert in the field, providing for the first time in print, a comprehensive and unique perspective of pilot plant production.

Scale-up

Modellübertragung in der Verfahrenstechnik

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527660461

Category: Science

Page: 295

View: 6916

Die Übertagung von Verfahren aus dem Labor-bzw. dem Techni-kumsmaßstab in den industriellen maßstab einer Produktiosanlage ist eine der wichtigsten ingenieurstechnischen Aufgaben in der chemischen Industrie. Die einzige zuverlässige Methode dazu basiert auf der Darstellung von Versuchsergebnissen im zutreffenden dimensions-analytischen Raum, der sich als maßstabsinvariant erweist. Das Buch ist in zwei Teile gegliedert: In der ersten Hälfte werden die vertiefte mathematische Vorkenntnisse dieses Themengebiet näherzubringen. Diskutiert werden die Grundlagen der Dimensionsanalyse, die Behandlung von temperaturabhängigen und von rheologischen Stoffwerten und die Modellübertragung bei Nichtverfügbarkeit von Modellstoffsystemen, sowie bei partieller Ähnlichkeit/ All dies wird dem leser anhand von 20 modernen Beispielen aus der heutigen verfahrenstechnischcen Praxis illustriert, der sich mit 25 in dieser Auflage neu hinzugekommenen Übungsaufgaben sein Verständnis aktive erarbeiten und anhand der Lösungen kontrollieren kann. Im zweitem Teil des Buches werden die einzelnen verfahrenstechnischen Grundoperationen aus den Bereichen mechanische, thermische und chemische Verfahrenstechnik aus der Sicht der Dimensionsanalyse und der Modellübertragung beispielhaft behandelt, und es werden für jede Operation die Maßstabsübertragungsregeln vorgestellt und diskutiert. Das vorliegende Buch wendet sich dementsprechend an Studenten wie auch bereits auf dem gebiet tätige Ingenieure, Chemiker und Verfahrenstechniker.

Scale-up Methodology for Chemical Processes

Author: Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier

Publisher: Editions TECHNIP

ISBN: 9782710806462

Category: Technology & Engineering

Page: 240

View: 4369

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Pharmaceutical Process Scale-Up

Author: Michael Levin

Publisher: CRC Press

ISBN: 082474196X

Category: Medical

Page: 584

View: 2349

Focusing on scientific and practical aspects of process scale-up, this resource details the theory and practice of transferring pharmaceutical processes from laboratory scale to the pilot plant and production scale. It covers parenteral and nonparenterel liquids and semi-solids, products derived from biotechnology, dry blending and powder handling, granulation and drying, fluid bed applications, compaction and tableting, and film coating and regulatory requirements for scale-up and postapproval changes. Drawing on the experience of twenty contributing researchers, the book employs dimensional analysis as a unified scientific approach to quantify similar processes on different scales.

Encyclopedia of Chemical Processing and Design

Volume 49 - Safety: OS1A Compliance to Separators: Vertical: Sizing with Computers

Author: John J. McKetta Jr

Publisher: CRC Press

ISBN: 9780824724993

Category: Science

Page: 536

View: 6864

"Written by engineers for engineers (with over 150 International Editorial Advisory Board members),this highly lauded resource provides up-to-the-minute information on the chemical processes, methods, practices, products, and standards in the chemical, and related, industries. "

Drug Discovery and Development, Volume 2

Drug Development

Author: Mukund S. Chorghade

Publisher: John Wiley & Sons

ISBN: 9780470085219

Category: Science

Page: 416

View: 2201

From first principles to real-world applications-here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines-from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and develop-?ment-from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing-including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrial chemists, biologists, biochemists, and executives who work in the pharmaceutical industry.

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527607765

Category: Science

Page: 296

View: 7574

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Scaleup of chemical processes

conversion from laboratory scale tests to successful commercial size design

Author: Attilio Bisio,Robert L. Kabel

Publisher: Wiley-Interscience

ISBN: N.A

Category: Technology & Engineering

Page: 699

View: 7082

Mixing in Continuous Flow Systems E. B. Nanman and B. A. Buffham This groundbreaking introductory study lets engineers and research scientists design and analyze complex flow and reaction systems, even with limited data. Specifically dealing with mixing effects important to the design of chemical reactors, it uses systems models typical of any large chemical plant or oil refinery to examine temporal mixing, or the mixing among particles or any conserved entities that have remained in the system for different lengths of time. In addition, it views mixing from a spatial perspective, treating it as a process that brings system components into closer physical proximity. Plus it reports the first steps toward unification of the temporal and spatial viewpoints of mixing. 1983 (0 471-86191-X) 271 pp. Structural Analysis and Design of Process Equipment Maan H. Jawad and James R. Farr Here is the most practical, up-to-date source available for information on the analysis and design of process equipment. It provides practicing engineers with clear guidance to the latest ASME Boiler and Vessel Code and offers advanced engineering students a concise introduction to the basic equations and rules used in the design of process vessels and components. Topics covered include a general introduction to the tools of the trade.an outline of the basic theory of plates and shells.a detailed analysis and design of components, defining procedures for designing vessel supports and illustrating the evaluation of stress due to wind and earthquake loads.and the design and analysis of specialized equipment, including tubesheet design in heat transfer equipment. 1984 (0 471-09207-X) 704 pp. Gas Treating with Chemical Solvents G. Astarita, D. W. Savage, and A. Bisio This rigorous blend of theory and practice provides a rational analysis of gas treating processes in which liquids are used to absorb acid gases from gaseous streams. It emphasizes those aspects unique to the use of chemically reactive solvents--liquids containing components that react chemically with the acid gases after they dissolve in the liquid phase And it also treats those aspects common to purely physical acid gas absorption processes. An ideal text for graduate students with a working knowledge of physical chemistry, classical gas absorption and mass transfer processes, it constitutes an exhaustive treatment of four important areas: industrial gas treating, theory, applications, and industrial problems. 1983 (0 471-05768-1) 493 pp.

Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 3527637168

Category: Science

Page: 370

View: 2293

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Fine Chemicals Manufacture

Technology and Engineering

Author: A. Cybulski,M.M. Sharma,R.A. Sheldon,J.A. Moulijn

Publisher: Gulf Professional Publishing

ISBN: 0080542298

Category: Science

Page: 564

View: 7844

The sector of fine chemicals, including pharmaceuticals, agrochemicals, dyes and pigments, fragrances and flavours, intermediates, and performance chemicals is growing fast. For obvious reasons chemistry is a key to the success in developing new processes for fine chemicals. However, as a rule, chemists formulate results of their work as recipes, which usually lack important information for process development. Fine Chemicals Manufacture, Technology and Engineering is intended to show what is needed to make the recipe more useful for process development purposes and to transform the recipe into an industrial process that will be safe, environmentally friendly, and profitable. The goal of this book is to form a bridge between chemists and specialists of all other branches involved in the scale-up of new processes or modification of existing processes with both a minimum effort and risk and maximum profit when commercializing the process. New techniques for scale-up and optimization of existing processes and improvements in the utilization of process equipment that have been developed in recent years are presented in the book.

Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier

ISBN: 0444627391

Category: Technology & Engineering

Page: 112

View: 6459

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Fundamentals of Food Biotechnology

Author: Byong H. Lee

Publisher: John Wiley & Sons

ISBN: 1118384911

Category: Science

Page: 544

View: 1138

Food biotechnology is the application of modern biotechnologicaltechniques to the manufacture and processing of food, for examplethrough fermentation of food (which is the oldest biotechnologicalprocess) and food additives, as well as plant and animal cellcultures. New developments in fermentation and enzyme technologicalprocesses, molecular thermodynamics, genetic engineering, proteinengineering, metabolic engineering, bioengineering, and processesinvolving monoclonal antibodies, nanobiotechnology and quorumsensing have introduced exciting new dimensions to foodbiotechnology, a burgeoning field that transcends many scientificdisciplines. Fundamentals of Food Biotechnology, 2nd edition is basedon the author’s 25 years of experience teaching on a foodbiotechnology course at McGill University in Canada. The book willappeal to professional food scientists as well as graduate andadvanced undergraduate students by addressing the latest excitingfood biotechnology research in areas such as genetically modifiedfoods (GMOs), bioenergy, bioplastics, functionalfoods/nutraceuticals, nanobiotechnology, quorum sensing andquenching. In addition, cloning techniques for bacterial and yeastenzymes are included in a “New Trends and Tools”section and selected references, questions and answers appear atthe end of each chapter. This new edition has been comprehensively rewritten andrestructured to reflect the new technologies, products and trendsthat have emerged since the original book. Many new aspectshighlight the short and longer term commercial potential of foodbiotechnology.

Practical Process Research and Development – A guide for Organic Chemists

Author: Neal G. Anderson

Publisher: Academic Press

ISBN: 0123865387

Category: Science

Page: 488

View: 5499

Designed to provide a comprehensive, step-by-step approach to organic process research and development in the pharmaceutical, fine chemical, and agricultural chemical industries, this book describes the steps taken, following synthesis and evaluation, to bring key compounds to market in a cost-effective manner. It describes hands-on, step-by-step, approaches to solving process development problems, including route, reagent, and solvent selection; optimising catalytic reactions; chiral syntheses; and "green chemistry." Second Edition highlights: • Reflects the current thinking in chemical process R&D for small molecules • Retains similar structure and orientation to the first edition. • Contains approx. 85% new material • Primarily new examples (work-up and prospective considerations for pilot plant and manufacturing scale-up) • Some new/expanded topics (e.g. green chemistry, genotoxins, enzymatic processes) • Replaces the first edition, although the first edition contains useful older examples that readers may refer to Provides insights into generating rugged, practical, cost-effective processes for the chemical preparation of "small molecules" Breaks down process optimization into route, reagent and solvent selection, development of reaction conditions, workup, crystallizations and more Presents guidelines for implementing and troubleshooting processes

Design of Multiphase Reactors

Author: Vishwas G. Pangarkar

Publisher: John Wiley & Sons

ISBN: 1118807561

Category: Science

Page: 536

View: 8681

"This resource offers a primer on simple design methods for multiphase reactors in the chemical process industries, particularly the fine chemicals industry. It provides the process design engineer with simple yet theoretically sound procedures. Different types of multiphase reactors are dealt with on an individual basis. The book focuses on the problem of predicting mass transfer rates in these reactors. It also contains finally worked examples that clearly illustrate how a highly complex MPR like the Stirred Tank Reactor (STR) can be designed using simple correlations which need only a scientific calculator"--

Scaleup and Design of Industrial Mixing Processes

Author: Gary B. Tatterson

Publisher: N.A

ISBN: 9780972663519

Category: Technology & Engineering

Page: 392

View: 4035

Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Bioreaction Engineering Principles

Second Edition

Author: Jens Nielsen,John Villadsen,Gunnar Lidén

Publisher: Springer

ISBN: 1461507677

Category: Technology & Engineering

Page: 528

View: 3640

This is the second edition of the text "Bioreaction Engineering Principles" by Jens Nielsen and John Villadsen, originally published in 1994 by Plenum Press (now part of Kluwer). Time runs fast in Biotechnology, and when Kluwer Plenum stopped reprinting the first edition and asked us to make a second, revised edition we happily accepted. A text on bioreactions written in the early 1990's will not reflect the enormous development of experimental as well as theoretical aspects of cellular reactions during the past decade. In the preface to the first edition we admitted to be newcomers in the field. One of us (JV) has had 10 more years of job training in biotechnology, and the younger author (IN) has now received international recognition for his work with the hottest topics of "modem" biotechnology. Furthermore we are happy to have induced Gunnar Liden, professor of chemical reaction engineering at our sister university in Lund, Sweden to join us as co-author of the second edition. His contribution, especially on the chemical engineering aspects of "real" bioreactors has been of the greatest value. Chapter 8 of the present edition is largely unchanged from the first edition. We wish to thank professor Martin Hjortso from LSU for his substantial help with this chapter.

Chemical Reactor Development

from Laboratory Synthesis to Industrial Production

Author: D. Thoenes

Publisher: Springer Science & Business Media

ISBN: 9780792330271

Category: Science

Page: 348

View: 9422

Chemical Reactor Development is written primarily for chemists and chemical engineers who are concerned with the development of a chemical synthesis from the laboratory bench scale, where the first successful experiments are performed, to the design desk, where the first commercial reactor is conceived. It is also written for those chemists and chemical engineers who are concerned with the further development of a chemical process with the objective of enhancing the performance of an existing industrial plant, as well as for students of chemistry and chemical engineering. In Part I, the `how' and the `why' of chemical reaction engineering are explained, particularly for those who are not familiar with this area. Part II deals with the effects of a number of physical phenomena on the outcome of chemical reactions, such as micro and meso-mixing and residence time distribution, mass transfer between two phases, and the formation of another phase, such as in precipitations. These scale-dependent effects are not only important in view of the conversion of chemical reactions, but also with regard to the selectivity, and in the case of solid products, to their morphology. In Part III, some applications are treated in a general way, including organic syntheses, the conversion and formation of inorganic solids, catalytic processes and polymerizations. The last chapter gives a review of the importance of the selectivity for product quality and for the purity of waste streams. For research chemists and chemical engineers whose work involves chemical reaction engineering. The book is also suitable as a supplementary graduate text.

Chemical Processes for a Sustainable Future

Author: Trevor Letcher,Janet Scott,Darrell Alec Patterson

Publisher: Royal Society of Chemistry

ISBN: 1849739757

Category: Science

Page: 800

View: 9513

Companion to: Materials for a sustainable future. Cambridge, UK: Royal Society of Chemistry, 2012.