Scaleup of chemical processes

conversion from laboratory scale tests to successful commercial size design

Author: Attilio Bisio,Robert L. Kabel

Publisher: Wiley-Interscience

ISBN: N.A

Category: Technology & Engineering

Page: 699

View: 9783

Mixing in Continuous Flow Systems E. B. Nanman and B. A. Buffham This groundbreaking introductory study lets engineers and research scientists design and analyze complex flow and reaction systems, even with limited data. Specifically dealing with mixing effects important to the design of chemical reactors, it uses systems models typical of any large chemical plant or oil refinery to examine temporal mixing, or the mixing among particles or any conserved entities that have remained in the system for different lengths of time. In addition, it views mixing from a spatial perspective, treating it as a process that brings system components into closer physical proximity. Plus it reports the first steps toward unification of the temporal and spatial viewpoints of mixing. 1983 (0 471-86191-X) 271 pp. Structural Analysis and Design of Process Equipment Maan H. Jawad and James R. Farr Here is the most practical, up-to-date source available for information on the analysis and design of process equipment. It provides practicing engineers with clear guidance to the latest ASME Boiler and Vessel Code and offers advanced engineering students a concise introduction to the basic equations and rules used in the design of process vessels and components. Topics covered include a general introduction to the tools of the trade.an outline of the basic theory of plates and shells.a detailed analysis and design of components, defining procedures for designing vessel supports and illustrating the evaluation of stress due to wind and earthquake loads.and the design and analysis of specialized equipment, including tubesheet design in heat transfer equipment. 1984 (0 471-09207-X) 704 pp. Gas Treating with Chemical Solvents G. Astarita, D. W. Savage, and A. Bisio This rigorous blend of theory and practice provides a rational analysis of gas treating processes in which liquids are used to absorb acid gases from gaseous streams. It emphasizes those aspects unique to the use of chemically reactive solvents--liquids containing components that react chemically with the acid gases after they dissolve in the liquid phase And it also treats those aspects common to purely physical acid gas absorption processes. An ideal text for graduate students with a working knowledge of physical chemistry, classical gas absorption and mass transfer processes, it constitutes an exhaustive treatment of four important areas: industrial gas treating, theory, applications, and industrial problems. 1983 (0 471-05768-1) 493 pp.

Pilot Plants and Scale-up of Chemical Processes II

Author: William Hoyle

Publisher: N.A

ISBN: 9780854047192

Category: Science

Page: 120

View: 4691

How do you translate bench chemistry into 10 -100 litre pilot plant scale? Drawing on the wealth of experience of its expert contributors, Pilot Plants and Scale-up of Chemical Processes II provides an insight into how methods, procedures and techniques can be optimised. Up-to-date and highly focused, this book addresses topics including the choice of phase-transfer catalyst, safe scale-up of both Grignard and organolithium reactions, and on-line techniques for examining crystallisation. Newly established collaborative industry/academia projects are discussed, along with other procedures that have a practical application in industry. As a source of innovative techniques and best current practice, this book is a must for process development and pilot plant chemists as well as chemical engineers.

Pilot Plants and Scale-up of Chemical Processes

Author: William Hoyle

Publisher: Royal Society of Chemistry

ISBN: N.A

Category: Science

Page: 97

View: 8718

One of the biggest challenges facing today's chemist and chemical engineer is the translation of bench chemistry to the pilot plant. This book provides expert insights into current best practice, and will prove an indispensable manual for all those involved in pilot plant design and scale-up implementation - process chemists, engineers and managers alike. The international expertise of the contributors covers a wide range of topics, and new material covered includes: the removal of heavy metals from effluent, heat flow calorimetry, low temperature processes, good manufacturing practice in pilot plants, design issues, the use of statistical methods in the running of pilot plants. Pilot Plants and Scale-Up of Chemical Processes is a must for all those who are, and wish to remain, expert in the field, providing for the first time in print, a comprehensive and unique perspective of pilot plant production.

Chemical Projects Scale Up

How to go from Laboratory to Commercial

Author: Joe M. Bonem

Publisher: Elsevier

ISBN: 0128137282

Category: Technology & Engineering

Page: 232

View: 8889

Chemical Projects Scale Up: How to Go from Laboratory to Commercial covers the chemical engineering steps necessary for taking a laboratory development into the commercial world. The book includes the problems associated with scale up, equipment sizing considerations, thermal characteristics associated with scale up, safety areas to consider, recycling considerations, operability reviews and economic viability. In addition to the process design aspects of commercializing the laboratory development, consideration is given to the utilization of a development in an existing plant. Explains how heat removal for exothermic reactions can be scaled up Outlines how a reactor can be sized from batch kinetic data Discusses how the plant performance of a new catalyst can be evaluated Presents how the economics of a new product/process can be developed Discusses the necessary evaluation of recycling in commercial plants

Scale-up Methodology for Chemical Processes

Author: Jean-Paul Euzen,Pierre Trambouze,Jean-Pierre Wauquier

Publisher: Editions TECHNIP

ISBN: 9782710806462

Category: Technology & Engineering

Page: 240

View: 8019

Having gained considerable experience in process development at the Institut FranCais du PEtrole, the authors present a design framework, a review of the available means of investigation, and several examples illustrating their methodology of industrial process scale up. The salient feature of the book is the fact that it addresses a subject which is vital in view of its economic repercussions, yet relatively unknown in technical and scientific circles, due to the confidentiality surrounding it.Contents: 1. Main guidelines of the methodology. 2. Various types of model. 3. Pilot plants and mock-ups. 4. Experimental techniques. 5. Applications to industrial process development. 6. Conclusions. References. Index.

Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: John Wiley & Sons

ISBN: 3527607765

Category: Science

Page: 296

View: 2071

Covering the important task of the scale-up of processes from the laboratory to the production scale, this easily comprehensible and transparent book is divided into two sections. The first part details the theoretical principles, introducing the subject for readers without a profound prior knowledge of mathematics. It discusses the fundamentals of dimensional analysis, the treatment of temperature-dependent and rheological material values and scale-up where model systems or not available or only partly similar. All this is illustrated by 20 real-world examples, while 25 exercises plus solutions new to this edition practice and monitor learning. The second part presents the individual basic operations and covers the fields of mechanical, thermal, and chemical process engineering with respect to dimensional analysis and scale-up. The rules for scale-up are given and discussed for each operation. Other additions to this second edition are dimensional analysis of pelleting processes, and a historical overview of dimensional analysis and modeling, while all the chapters have been updated to take the latest literature into account. Written by a specialist with more than 40 years of experience in the industry, this book is specifically aimed at students as well as practicing engineers, chemists and process engineers already working in the field.

Process Understanding

For Scale-Up and Manufacture of Active Ingredients

Author: Ian Houson

Publisher: John Wiley & Sons

ISBN: 352763715X

Category: Science

Page: 370

View: 9424

Process Understanding is the underpinning knowledge that allows the manufacture of chemical entities to be carried out routinely, robustly and to the required standard of quality. This area has gained in importance over the last few years, particularly due to the recent impetus from the USA`s Food and Drug Administration. This book covers the multidisciplinary aspects required for successful process design, safety, modeling, scale-up, PAT, pilot plant implementation, plant design as well the rapidly expanding area of outsourcing. In discussing what process understanding means to different disciplines and sectors throughout a product`s life cycle, this handbook and ready reference reveals the factors important to the development and manufacture of chemicals. The book focuses on the fundamental scientific understanding necessary. for a smoother technical transfer between the disciplines, leading to more effective and effi cient process development and manufacturing. A range of case studies are used to exemplify and illustrate the main issues raised. As a result, readers will appreciate that process understanding can deliver a real competitive advantage within the pharmaceuticals and fine chemicals industry. This book serves as an aid to meeting the stringent regulations required by the relevant authorities through demonstrable understanding of the underlying science.

Scaling Chemical Processes

Practical Guides in Chemical Engineering

Author: Jonathan Worstell

Publisher: Butterworth-Heinemann

ISBN: 0128047690

Category: Technology & Engineering

Page: 186

View: 1757

Scaling Chemical Processes: Practical Guides in Chemical Engineering is one of a series of short texts that each provides a focused introductory view on a single subject. The full library spans the main topics in the chemical process industries for engineering professionals who require a basic grounding in various related topics. They are ‘pocket publications’ that the professional engineer can easily carry with them or access electronically while working. Each text is highly practical and applied, and presents first principles for engineers who need to get up to speed in a new area fast. The focused facts provided in each guide will help you converse with experts in the field, attempt your own initial troubleshooting, check calculations, and solve rudimentary problems. This book discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant. It bases scaling on similarity principles and uses dimensional analysis to derive the dimensionless parameters necessary to ensure a successful chemical process development program. This series is fully endorsed and co-branded by the IChemE, and they help to promote the series. Offers practical, short, concise information on the basics to help you get an answer or teach yourself a new topic quickly Includes industry examples to help you solve real world problems Provides key facts for professionals in convenient single subject volumes Discusses scaling chemical processes from a laboratory through a pilot plant to a commercial plant

Industrial Process Scale-up

A Practical Innovation Guide from Idea to Commercial Implementation

Author: Jan Harmsen

Publisher: Elsevier

ISBN: 0444627391

Category: Technology & Engineering

Page: 112

View: 8766

This book will help industrial process innovators in research, development and commercial start-up to assess the risks of commercial-scale implementation and provide them with practical guidelines and methods to reduce the risks to acceptable levels. The book can also be used in co-operation with industrial R&D people and academic researchers to shape open innovation programs and in education as a reference book for process innovation courses. Offers easily accessible, step-by-step, and concise guidelines for industrial process scale-up Explains each stage of the innovation funnel: research, development, demonstration, commercial implementation for any process type and branch Based on industrial experiences and practices, which reduces the risks of commercial scale implementation of new processes to acceptable levels and reduces cost and time of process innovation Very clear, attractive layout, using text boxes that contain clarifying notes and additional information on specific topics, which makes it a quick reference of main subjects and additional information

Chemical Engineering

Modelling, Simulation and Similitude

Author: Tanase Gh. Dobre,Jose G. Sanchez Marcano

Publisher: John Wiley & Sons

ISBN: 3527306072

Category: Science

Page: 568

View: 2459

A description of the use of computer aided modeling and simulation in the development, integration and optimization of industrial processes. The two authors elucidate the entire procedure step-by-step, from basic mathematical modeling to result interpretation and full-scale process performance analysis. They further demonstrate similitude comparisons of experimental results from different systems as a tool for broadening the applicability of the calculation methods. Throughout, the book adopts a very practical approach, addressing actual problems and projects likely to be encountered by the reader, as well as fundamentals and solution strategies for complex problems. It is thus equally useful for student and professional engineers and chemists involved in industrial process and production plant design, construction or upgrading.

Pharmaceutical Process Chemistry for Synthesis

Rethinking the Routes to Scale-Up

Author: Peter J. Harrington

Publisher: John Wiley & Sons

ISBN: 9780470922866

Category: Science

Page: 448

View: 1128

There is a need to explain that generic versions of a drug may not be manufactured by the same process as brand-name drugs and that the different processes may have dramatically different environmental impacts. Two global forces are at odds today—the push for "greener" processes and the push for lower drug prices. This book brings this conflict into sharp focus by discussing in detail the published process chemistry for top-selling small molecule drugs. Providing insights about process route selection, choice of reagents, and reaction conditions, Pharmaceutical Process Chemistry for Synthesis guides process chemists in identifying best processes for manufacturing these blockbuster drugs as they lose patent protection. Further, it highlights the strategies and methodology that might be useful for expediting the process research and development of the blockbusters of the future. Written from a refreshingly objective perspective, this book is essential for process chemists who need to devise practical syntheses for increasingly complex drugs in a constantly decreasing time frame.

Scaleup and Design of Industrial Mixing Processes

Author: Gary B. Tatterson

Publisher: N.A

ISBN: 9780972663519

Category: Technology & Engineering

Page: 392

View: 8326

Mistakes in process scaleup can be costly. This text is a comprehensive and highly practical source to all types of mixing and scaleup issues.

Chemical Reactor Design, Optimization, and Scaleup

Author: E. Bruce Nauman

Publisher: John Wiley & Sons

ISBN: 0470282061

Category: Technology & Engineering

Page: 656

View: 3966

The classic reference, now expanded and updated Chemical Reactor Design, Optimization, and Scaleup is the authoritative sourcebook on chemical reactors. This new Second Edition consolidates the latest information on current optimization and scaleup methodologies, numerical methods, and biochemical and polymer reactions. It provides the comprehensive tools and information to help readers design and specify chemical reactors confidently, with state-of-the-art skills. This authoritative guide: Covers the fundamentals and principles of chemical reactor design, along with advanced topics and applications Presents techniques for dealing with varying physical properties in reactors of all types and purposes Includes a completely new chapter on meso-, micro-, and nano-scale reactors that addresses such topics as axial diffusion in micro-scale reactors and self-assembly of nano-scale structures Explains the method of false transients, a numerical solution technique Includes suggestions for further reading, problems, and, when appropriate, scaleup or scaledown considerations at the end of each chapter to illustrate industrial applications Serves as a ready reference for explained formulas, principles, and data This is the definitive hands-on reference for practicing professionals and an excellent textbook for courses in chemical reactor design. It is an essential resource for chemical engineers in the process industries, including petrochemicals, biochemicals, microelectronics, and water treatment.

The Pilot Plant Real Book

A Unique Handbook for the Chemical Process Industry

Author: Francis X. McConville

Publisher: Fxm Engineering & Design

ISBN: 9780972176927

Category: Science

Page: 320

View: 6585

Dimensional Analysis and Scale-up in Chemical Engineering

Author: Marko Zlokarnik

Publisher: Springer Science & Business Media

ISBN: 3642766730

Category: Science

Page: 178

View: 4652

Contemporary Chemical Process Engineers face complex design and research problems. Temperature-dependent physical properties and non-Newtonian flow behavior of substances in a process cannot be predicted by numerical mathematics. Scaling-up equipment for processing can often only be done with partial similarity methods. Standard textbooks often neglect topics like dimensional analysis, theory of similarity and scale-up. This book fills this gap! It is aimed both at university students and the process engineer. It presents dimensional analysis very comprehensively with illustrative examples of mechanical, thermal and chemical processes.

Chemical Process Equipment

Selection and Design

Author: James R. Couper,W. Roy Penney,James R. Fair, PhD

Publisher: Elsevier

ISBN: 0123972361

Category: Technology & Engineering

Page: 864

View: 5165

Chemical Process Equipment is a results-oriented reference for engineers who specify, design, maintain or run chemical and process plants. This book delivers information on the selection, sizing and operation of process equipment in a format that enables quick and accurate decision making on standard process and equipment choices, saving time, improving productivity, and building understanding. Coverage emphasizes common real-world equipment design rather than experimental or esoteric and focuses on maximizing performance. Legacy reference for chemical and related engineers who work with vendors to design, specify and make final equipment selection decisions Copious examples of successful applications, with supporting schematics and data to illustrate the functioning and performance of equipment Provides equipment rating forms and manufacturers’ data, worked examples, valuable shortcut methods, and rules of thumb to demonstrate and support the design process Heavily illustrated with line drawings and schematics to aid understanding, as well as graphs and tables to illustrate performance data

Process Plant Design

Heinemann Chemical Engineering Series

Author: J R Backhurst,J H Harker

Publisher: Butterworth-Heinemann

ISBN: 1483162389

Category: Science

Page: 414

View: 1329

Process Plant Design provides an introduction to the basic principles of plant design and shows how the fundamentals of design can be blended with commercial aspects to produce a final specification; how textbook parameters can be applied to the solution of real problems; and how training in chemical engineering can best be utilized in the industrial sphere. It has been assumed that the reader knows how to calculate a heat transfer coefficient and the height of an absorber, for example, and the bulk of the book is concerned with the translation of such parameters into plant items which are ultimately linked into the production unit. The book follows a fairly logical sequence in which flowsheets, heat and mass balances, for example, are considered before attention is paid to the design of plant items, exchangers, columns, and so on. Because of the vital role of economics in any design function, costing is dealt with early in the book and the principles further developed as appropriate. Rarely is the plant designer concerned with the design of smaller and standard items of equipment, and hence considerable emphasis is placed on the selection of such items. This section may prove of particular value to the engineer in industry, especially if he has not the backing of comprehensive technical manuals produced by the larger companies. Finally, an attempt is made to draw together the many facets of equipment design into one specification for the complete plant, and the many aspects relating to the completed unit are introduced in a final section.

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology

Author: Alexandru Mihai Grumezescu

Publisher: William Andrew

ISBN: 0128136308

Category: Science

Page: 696

View: 7341

Nanoscale Fabrication, Optimization, Scale-up and Biological Aspects of Pharmaceutical Nanotechnology focuses on the fabrication, optimization, scale-up and biological aspects of pharmaceutical nanotechnology. In particular, the following aspects of nanoparticle preparation methods are discussed: the need for less toxic reagents, simplification of the procedure to allow economic scale-up, and optimization to improve yield and entrapment efficiency. Written by a diverse range of international researchers, the chapters examine characterization and manufacturing of nanomaterials for pharmaceutical applications. Regulatory and policy aspects are also discussed. This book is a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about how nanomaterials can best be utilized. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Modeling of Chemical Kinetics and Reactor Design

Author: A. Kayode Coker

Publisher: Gulf Professional Publishing

ISBN: 9780884154815

Category: Technology & Engineering

Page: 1096

View: 3822

Selecting the best type of reactor for any particular chemical reaction, taking into consideration safety, hazard analysis, scale-up, and many other factors is essential to any industrial problem. An understanding of chemical reaction kinetics and the design of chemical reactors is key to the success of the of the chemist and the chemical engineer in such an endeavor. This valuable reference volume conveys a basic understanding of chemical reactor design methodologies, incorporating control, hazard analysis, and other topics not covered in similar texts. In addition to covering fluid mixing, the treatment of wastewater, and chemical reactor modeling, the author includes sections on safety in chemical reaction and scale-up, two topics that are often neglected or overlooked. As a real-world introduction to the modeling of chemical kinetics and reactor design, the author includes a case study on ammonia synthesis that is integrated throughout the text. The text also features an accompanying CD, which contains computer programs developed to solve modeling problems using numerical methods. Students, chemists, technologists, and chemical engineers will all benefit from this comprehensive volume. Shows readers how to select the best reactor design, hazard analysis, and safety in design methodology Features computer programs developed to solve modeling problems using numerical methods